Contributions
Abstract: 152
Type: Oral
Little is known about the factors that govern the highly variable course of multiple sclerosis. Epidemiological studies indicate that genetic variation is likely to be involved which means that genome wide association studies (GWAS) have the potential to reveal the key biological progresses underlying this critical aspect of the disease. The approach has been fabulously successful at identifying genetic variants which influence risk of the disease, although to date the lack of tissue specific annotation has limited the biological insights provided by these discoveries. Fortunately advances in the Human Epigenome Project mean that this knowledge gap is rapidly closing. Defining and measuring progression in very large samples sizes are fundamental prerequisites that will need to be established for GWAS to be able to deliver the same success in terms of the progression.
Disclosure: Stephen Sawcer: Nothing to disclose
Abstract: 152
Type: Oral
Little is known about the factors that govern the highly variable course of multiple sclerosis. Epidemiological studies indicate that genetic variation is likely to be involved which means that genome wide association studies (GWAS) have the potential to reveal the key biological progresses underlying this critical aspect of the disease. The approach has been fabulously successful at identifying genetic variants which influence risk of the disease, although to date the lack of tissue specific annotation has limited the biological insights provided by these discoveries. Fortunately advances in the Human Epigenome Project mean that this knowledge gap is rapidly closing. Defining and measuring progression in very large samples sizes are fundamental prerequisites that will need to be established for GWAS to be able to deliver the same success in terms of the progression.
Disclosure: Stephen Sawcer: Nothing to disclose