Contributions
Abstract: P991
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Environmental risk factors
Introduction: The United Kingdom (UK) multiple sclerosis (MS) tissue bank is a country-wide prospective donor scheme offering detailed clinical information with well characterised tissue samples for use in research. In a local population in South-East Wales it has been shown that area deprivation has an impact on the disease course in MS. We investigated this phenomenon in an English population-based national cohort.
Methods: Data were collected on the UK MS Tissue bank population in whom we had full lifetime address history, and full details of their MS milestones: relapse rate in the first two years, and age of onset, progression, wheelchair use and death. Neighbourhood socioeconomic status (SES) was categorised using the English Index of Multiple Deprivations (IMD) based upon the small geographical areas in which they lived over their lifetime (“lower layer super output areas” - encompassing approximately 1,500 people). Data were analysed using multi-variate analysis.
Results: A full address history and MS milestone history was available in 174 subjects. The average age of onset was 31.7 years, age of progression 44.4 years, age of wheelchair use 51.5 years and age of death 63.3 years. The average number of relapses in the first two years was 2.2. A multi-variate analysis demonstrated that a higher average area deprivation prior to progression, based on all prior addresses of the subject, were associated with an earlier age of progression (p=0.011). A higher average area deprivation prior to wheelchair use again was associated with earlier age of requiring wheelchair use (p=0.037). There was no association between these MS milestones and average area deprivation scores, based on all subsequent addresses of the subject after reaching these two milestones.
Conclusion: This study argues that there is an impact of deprivation on the time to achieving MS disease milestones. This research supports the hypothesis that lower socio economic status is associated with health inequalities in MS outcomes.
Disclosure:
Byrone Mitchell: nothing to disclose
Joel Raffel: nothing to disclose
Richard Nicholas: Bayer, Biogen, Genzyme, Merck Serono, Roche - honorarium for speaking, advisory boards. Biogen, Genzyme, Novartis - funds for organising education, staff. Biogen, Novartis - Principal investigator.
Abstract: P991
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Environmental risk factors
Introduction: The United Kingdom (UK) multiple sclerosis (MS) tissue bank is a country-wide prospective donor scheme offering detailed clinical information with well characterised tissue samples for use in research. In a local population in South-East Wales it has been shown that area deprivation has an impact on the disease course in MS. We investigated this phenomenon in an English population-based national cohort.
Methods: Data were collected on the UK MS Tissue bank population in whom we had full lifetime address history, and full details of their MS milestones: relapse rate in the first two years, and age of onset, progression, wheelchair use and death. Neighbourhood socioeconomic status (SES) was categorised using the English Index of Multiple Deprivations (IMD) based upon the small geographical areas in which they lived over their lifetime (“lower layer super output areas” - encompassing approximately 1,500 people). Data were analysed using multi-variate analysis.
Results: A full address history and MS milestone history was available in 174 subjects. The average age of onset was 31.7 years, age of progression 44.4 years, age of wheelchair use 51.5 years and age of death 63.3 years. The average number of relapses in the first two years was 2.2. A multi-variate analysis demonstrated that a higher average area deprivation prior to progression, based on all prior addresses of the subject, were associated with an earlier age of progression (p=0.011). A higher average area deprivation prior to wheelchair use again was associated with earlier age of requiring wheelchair use (p=0.037). There was no association between these MS milestones and average area deprivation scores, based on all subsequent addresses of the subject after reaching these two milestones.
Conclusion: This study argues that there is an impact of deprivation on the time to achieving MS disease milestones. This research supports the hypothesis that lower socio economic status is associated with health inequalities in MS outcomes.
Disclosure:
Byrone Mitchell: nothing to disclose
Joel Raffel: nothing to disclose
Richard Nicholas: Bayer, Biogen, Genzyme, Merck Serono, Roche - honorarium for speaking, advisory boards. Biogen, Genzyme, Novartis - funds for organising education, staff. Biogen, Novartis - Principal investigator.