Contributions
Abstract: P923
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Goals: The main objective of our study is to characterize the optical neuropathy (ON) at the moment of diagnosis as well as to assess factors that may predispose to evolve to Multiple Sclerosis (MS).
Methods: We performed a cross-sectional, descriptive and retrospective study of a series of 98 patients of our unit whose first symptom of their disease was visual deficit, being diagnosed as optic neuropathy. We picked up their main features in a database and performed an analysis of frequencies, as well as a multivariate analysis to assess which characteristics were associated with the evolution to MS.
Results: We analysed 98 patients, 70 (71%) females and 28(29%) men, with an average age of 33 years. The affected eye was right 34(35%), left 49(50%), and both in 13(13%); retro-bulbar location in 85%.
Only 76(77%) patients were studied when ON occur, within these, oligoclonalfb bands (OCB) in cerebrospinal fluid (CSF) were positive in 59%, the Aquaporin-4-specific serum autoantibodies in 2 cases, and the serology was positive in another 2; with respect to the magnetic resonance imaging (MRI) in 24(35%) was normal, 31(45%) findings compatible with ME, 10(15%) lesions suggestive but not defining ME, and in 4(6%) cases other pathologic findings.
Of all the patients analysed the final diagnosis in 63(64%) patients was MS, in 7(8%) Isolated clinical syndrome (ICS), in 2(2%) Neuromyelitis Optica (NMO), in 4 (4%) chronic relapsing inflammatory optic neuropathy, in 5(5%) ischemic optic neuropathy, and in 9 (9%) other less frequent diseases.
If we analyse only patients who were finally diagnosed of MS we observed that there are significant differences with the rest of patients in regard to the following characteristic: 93.7% retrobulbar location (p< 0.002), 93.7% monocular presentation (p 0.002), the OCB was positive in 84.6% (p< 0.0001), and lesions in MRI were suggestive of MS in 85% of the patients (p< 0.0001).
Conclusion: We have performed a describing and detailed analysis of our series of patients with the diagnosis of ON, in another hand we have observed that in the patients finally diagnosed with MS, the clinical presentation is more frequently monocular and retrobulbar, the lesions in MRI are suggestive of MS and have presence of OCB in CSF, so this data can be used to establish a prognosis at the moment of diagnosis of ON.
Disclosure: No conflict of interest
Abstract: P923
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Goals: The main objective of our study is to characterize the optical neuropathy (ON) at the moment of diagnosis as well as to assess factors that may predispose to evolve to Multiple Sclerosis (MS).
Methods: We performed a cross-sectional, descriptive and retrospective study of a series of 98 patients of our unit whose first symptom of their disease was visual deficit, being diagnosed as optic neuropathy. We picked up their main features in a database and performed an analysis of frequencies, as well as a multivariate analysis to assess which characteristics were associated with the evolution to MS.
Results: We analysed 98 patients, 70 (71%) females and 28(29%) men, with an average age of 33 years. The affected eye was right 34(35%), left 49(50%), and both in 13(13%); retro-bulbar location in 85%.
Only 76(77%) patients were studied when ON occur, within these, oligoclonalfb bands (OCB) in cerebrospinal fluid (CSF) were positive in 59%, the Aquaporin-4-specific serum autoantibodies in 2 cases, and the serology was positive in another 2; with respect to the magnetic resonance imaging (MRI) in 24(35%) was normal, 31(45%) findings compatible with ME, 10(15%) lesions suggestive but not defining ME, and in 4(6%) cases other pathologic findings.
Of all the patients analysed the final diagnosis in 63(64%) patients was MS, in 7(8%) Isolated clinical syndrome (ICS), in 2(2%) Neuromyelitis Optica (NMO), in 4 (4%) chronic relapsing inflammatory optic neuropathy, in 5(5%) ischemic optic neuropathy, and in 9 (9%) other less frequent diseases.
If we analyse only patients who were finally diagnosed of MS we observed that there are significant differences with the rest of patients in regard to the following characteristic: 93.7% retrobulbar location (p< 0.002), 93.7% monocular presentation (p 0.002), the OCB was positive in 84.6% (p< 0.0001), and lesions in MRI were suggestive of MS in 85% of the patients (p< 0.0001).
Conclusion: We have performed a describing and detailed analysis of our series of patients with the diagnosis of ON, in another hand we have observed that in the patients finally diagnosed with MS, the clinical presentation is more frequently monocular and retrobulbar, the lesions in MRI are suggestive of MS and have presence of OCB in CSF, so this data can be used to establish a prognosis at the moment of diagnosis of ON.
Disclosure: No conflict of interest