Contributions
Abstract: P922
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: Optic neuritis (ON) is an optic nerve disease, manifested by decline in visual functions and relative pupillary afferent defect of the affected eye. ON is the presenting feature of multiple sclerosis (MS) in 15-20% patients and almost half of the patients develop ON during the course of disease.
Objective: Assessment of retinal oxygen saturation, of the thickness of retinal nerve fiber layer (RNFL) and of functional changes occurring in the optic nerve during ON.
Methods: Twenty-five patients with ON were enrolled during 2015 (17 females, 8 male, age 34.7 ± 8.9 years, 17 patients with the clinically isolated syndrome - CIS, 8 patients with relapsing-remitting from of MS). All patients were examined using optical coherence tomography (Cirrus HD-OCT 4000, Carl Zeiss, Jena, Germany), automatic optical oximetry (Oxymap, ehf. Reykjavik, Island), and using visual evoked potentials (Metronic Keypoint®, Minneapolis, USA).
Results: We detected statistically significant larger difference between arterial and venous saturation in the retina of ON patients, whereas there were no significant changes of the RNFL thickness. There were no effects of gender or the form of the disease. We found significantly lower optic nerve conduction velocity in affected eye.
Conclusion: Lower level of oxygen saturation in the retinal vessels is apparently caused by a higher metabolic demand. We suggest that in the early stage of ON, oximetry reflects the inflammatory changes in the affected eye earlier and is more appropriate to assess pathological changes than optical coherence tomography. Our next goal is to assess the long-term changes after the recovery of ON.
Research supproted by IGA_LF_2016_020 and Institutional Support of Research Organization MZ CR RV FNOL 2015
Disclosure: nothing to disclose
Abstract: P922
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: Optic neuritis (ON) is an optic nerve disease, manifested by decline in visual functions and relative pupillary afferent defect of the affected eye. ON is the presenting feature of multiple sclerosis (MS) in 15-20% patients and almost half of the patients develop ON during the course of disease.
Objective: Assessment of retinal oxygen saturation, of the thickness of retinal nerve fiber layer (RNFL) and of functional changes occurring in the optic nerve during ON.
Methods: Twenty-five patients with ON were enrolled during 2015 (17 females, 8 male, age 34.7 ± 8.9 years, 17 patients with the clinically isolated syndrome - CIS, 8 patients with relapsing-remitting from of MS). All patients were examined using optical coherence tomography (Cirrus HD-OCT 4000, Carl Zeiss, Jena, Germany), automatic optical oximetry (Oxymap, ehf. Reykjavik, Island), and using visual evoked potentials (Metronic Keypoint®, Minneapolis, USA).
Results: We detected statistically significant larger difference between arterial and venous saturation in the retina of ON patients, whereas there were no significant changes of the RNFL thickness. There were no effects of gender or the form of the disease. We found significantly lower optic nerve conduction velocity in affected eye.
Conclusion: Lower level of oxygen saturation in the retinal vessels is apparently caused by a higher metabolic demand. We suggest that in the early stage of ON, oximetry reflects the inflammatory changes in the affected eye earlier and is more appropriate to assess pathological changes than optical coherence tomography. Our next goal is to assess the long-term changes after the recovery of ON.
Research supproted by IGA_LF_2016_020 and Institutional Support of Research Organization MZ CR RV FNOL 2015
Disclosure: nothing to disclose