Contributions
Abstract: P921
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Objective: We determined the relation of myopia, as measured by spherical equivalent, to retinal thickness in the nerve fiber layer and macula in patients with multiple sclerosis (MS) compared to disease-free controls using optical coherence tomography (OCT).
Background: Myopia is associated with thinning of the peripapillary retinal nerve fiber layer (RNFL) by OCT in healthy patients, and longer axial length, captured by spherical equivalent (spherical correction + 0.5*cylinder), produces RNFL thinning. The extent to which myopic spherical equivalent could affect the relation between MS vs. disease-free control status and RNFL and ganglion cell layer (GCL+IPL) thickness has not been investigated.
Methods: Participants with MS and disease-free controls enrolled in an ongoing collaborative study of MS visual outcomes completed spectral-domain OCT to determine peripapillary RNFL and GCL+IPL thicknesses. The 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) and 10-Item Neuro-Ophthalmic Supplement, as well as high-contrast visual acuity and low-contrast letter acuity were administered.
Results: Among disease-free controls (n=65 eyes), greater spherical equivalent in the myopic direction was a predictor of thinner RNFL (p< 0.001) and GCL+IPL (p=0.005, GEE models, accounting for age and within-patient, inter-eye correlations). In the MS cohort (n=291 eyes), greater degrees of myopia were also associated with RNFL thinning (p< 0.001). These associations were similar among MS eyes with (n=101 eyes) and without a history of optic neuritis (n=180 eyes). Accounting for MS vs. control status in the models lessened the significance of the association of greater myopia with RNFL and GCL+IPL thinning, but did not account for this relationship completely.
Conclusions: Myopia is a significant contributor to RNFL and GCL+IPL thinning in both disease-free controls and among patients with MS. Even among eyes with a history of optic neuritis, the potential influence of myopia should be taken into account when interpreting group and individual data from OCT measurements.
Disclosure: R. Nolan: None. D. Laura: None. P. Calabresi: ; Received consulting honorarium from Abbott and Vertex., Grant support from Novartis, MedImmune and Biogen. E. Frohman: ; Dr. Frohman has participated in the speakers´ bureau for Teva Neurosciences, Acorda, and Novartis and has received consulting fees from TEVA Neurosciences, and Acorda. S. Galetta: ; Biogen Idec- Consulting
Genzyme- Consulting. L. Balcer: ; Consultant/advisor, Biogen Idec, Genzyme.
Abstract: P921
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Objective: We determined the relation of myopia, as measured by spherical equivalent, to retinal thickness in the nerve fiber layer and macula in patients with multiple sclerosis (MS) compared to disease-free controls using optical coherence tomography (OCT).
Background: Myopia is associated with thinning of the peripapillary retinal nerve fiber layer (RNFL) by OCT in healthy patients, and longer axial length, captured by spherical equivalent (spherical correction + 0.5*cylinder), produces RNFL thinning. The extent to which myopic spherical equivalent could affect the relation between MS vs. disease-free control status and RNFL and ganglion cell layer (GCL+IPL) thickness has not been investigated.
Methods: Participants with MS and disease-free controls enrolled in an ongoing collaborative study of MS visual outcomes completed spectral-domain OCT to determine peripapillary RNFL and GCL+IPL thicknesses. The 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) and 10-Item Neuro-Ophthalmic Supplement, as well as high-contrast visual acuity and low-contrast letter acuity were administered.
Results: Among disease-free controls (n=65 eyes), greater spherical equivalent in the myopic direction was a predictor of thinner RNFL (p< 0.001) and GCL+IPL (p=0.005, GEE models, accounting for age and within-patient, inter-eye correlations). In the MS cohort (n=291 eyes), greater degrees of myopia were also associated with RNFL thinning (p< 0.001). These associations were similar among MS eyes with (n=101 eyes) and without a history of optic neuritis (n=180 eyes). Accounting for MS vs. control status in the models lessened the significance of the association of greater myopia with RNFL and GCL+IPL thinning, but did not account for this relationship completely.
Conclusions: Myopia is a significant contributor to RNFL and GCL+IPL thinning in both disease-free controls and among patients with MS. Even among eyes with a history of optic neuritis, the potential influence of myopia should be taken into account when interpreting group and individual data from OCT measurements.
Disclosure: R. Nolan: None. D. Laura: None. P. Calabresi: ; Received consulting honorarium from Abbott and Vertex., Grant support from Novartis, MedImmune and Biogen. E. Frohman: ; Dr. Frohman has participated in the speakers´ bureau for Teva Neurosciences, Acorda, and Novartis and has received consulting fees from TEVA Neurosciences, and Acorda. S. Galetta: ; Biogen Idec- Consulting
Genzyme- Consulting. L. Balcer: ; Consultant/advisor, Biogen Idec, Genzyme.