Contributions
Abstract: P918
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: Neuromyelitis Optica (NMO) is an autoimmune demyelinating disease that affects the optic nerve and spinal cord. Anti-Aquaporin-4 antibody (AQP-4 Ab) has been found to be a highly specific and sensitive diagnostic marker for NMO. However there are only a few studies analyzing the relations between the level of AQP4-Ab and NMO clinical presentation.
Objective: To investigate the correlation between AQP4-Ab titter and visual performance of NMO patients at disease onset.
Methods: We evaluated NMO patients with single or recurrent episodes of optic neuritis or transverse myelitis or both having positive AQP4-Ab test. The levels of AQP4-Ab in patients with (N=23) or without (N=27) radiologically active lesions in the optic nerve were tested using ElisaRSRTM AQP4 Ab Version 2 kit (RSR, UK, positive cut off ≥3.0 µg/ml). Pearson correlation between AQP4-Ab titer and visual acuity in the most affected eye was also calculated. AQP4-Ab levels were compared between patients with low vision (visual acuity 6/120 or less including finger counting, light perception and blindness), patients with medium vision loss (6/12 to 6/60) and NMO patients with normal vision (6/6 to 6/12). Additionally, AQP4-Ab levels were compared between patients with and without radiologically active lesions in the optic nerve.
Results: Forty AQP4-Ab positive NMO patients, 23 females, age 38.5±2.4 years, EDSS=3.3±0.3, were included in the analysis. AQP4-Ab titer range was 3.2 to 199.0, and positively correlated with visual acuity in the affected eye (r= 0.52, p=0.005). Low and medium vision patients (n=18) were characterized by significantly higher AQP4-Ab titer than patients with normal vision (n=22), 81.1±17.0 vs 17.0±4.7 µg/ml, p=0002, respectively. Higher AQP4-Ab titer at onset was associated with bilateral optic nerve involvement as well as with motor involvement. Comparison of AQP-4 Ab levels between patients with and without radiologically active lesions demonstrated higher titers in the group with active lesions 61.5±10 vs 19.8±3.2, µg/ml p=0.01, respectively.
Conclusion: Measuring AQP4-Ab titers is of significance to the severity of NMO ocular involvement. NMO patients with higher AQP4-Ab levels demonstrate more severe disease both clinically and radiologically.
Disclosure: Nothing to disclose
Abstract: P918
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: Neuromyelitis Optica (NMO) is an autoimmune demyelinating disease that affects the optic nerve and spinal cord. Anti-Aquaporin-4 antibody (AQP-4 Ab) has been found to be a highly specific and sensitive diagnostic marker for NMO. However there are only a few studies analyzing the relations between the level of AQP4-Ab and NMO clinical presentation.
Objective: To investigate the correlation between AQP4-Ab titter and visual performance of NMO patients at disease onset.
Methods: We evaluated NMO patients with single or recurrent episodes of optic neuritis or transverse myelitis or both having positive AQP4-Ab test. The levels of AQP4-Ab in patients with (N=23) or without (N=27) radiologically active lesions in the optic nerve were tested using ElisaRSRTM AQP4 Ab Version 2 kit (RSR, UK, positive cut off ≥3.0 µg/ml). Pearson correlation between AQP4-Ab titer and visual acuity in the most affected eye was also calculated. AQP4-Ab levels were compared between patients with low vision (visual acuity 6/120 or less including finger counting, light perception and blindness), patients with medium vision loss (6/12 to 6/60) and NMO patients with normal vision (6/6 to 6/12). Additionally, AQP4-Ab levels were compared between patients with and without radiologically active lesions in the optic nerve.
Results: Forty AQP4-Ab positive NMO patients, 23 females, age 38.5±2.4 years, EDSS=3.3±0.3, were included in the analysis. AQP4-Ab titer range was 3.2 to 199.0, and positively correlated with visual acuity in the affected eye (r= 0.52, p=0.005). Low and medium vision patients (n=18) were characterized by significantly higher AQP4-Ab titer than patients with normal vision (n=22), 81.1±17.0 vs 17.0±4.7 µg/ml, p=0002, respectively. Higher AQP4-Ab titer at onset was associated with bilateral optic nerve involvement as well as with motor involvement. Comparison of AQP-4 Ab levels between patients with and without radiologically active lesions demonstrated higher titers in the group with active lesions 61.5±10 vs 19.8±3.2, µg/ml p=0.01, respectively.
Conclusion: Measuring AQP4-Ab titers is of significance to the severity of NMO ocular involvement. NMO patients with higher AQP4-Ab levels demonstrate more severe disease both clinically and radiologically.
Disclosure: Nothing to disclose