Abstract: P917
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: Severe isolated, bilateral and/or recurrent optic neuritis (ON) may herald neuromyelitis optica spectrum disorders (NMOsd). However, a broad range of etiologies can be observed. Thus, establishing the correct diagnosis can have an impact in terms of disease specific treatment and prognosis.
Objectives: To report the features, differential diagnosis and prognosis of atypical ON patients at onset in an Argentine population.
Methods: Retrospective study that included 22 sequential patients with atypical features of first acute ON inmmune-mediated at onset, without signs concern for systemic disease, who were referred for consideration of NMOsd, multiple sclerosis ON (MSON), chronic relapsing inflammatory ON (CRION), single isolated ON (SION) or any other inflammatory CNS disorders. Aquaporin-4 antibody (AQP4-Ab) was performed in all patients.
Results: AQP4-ab seropositive proportion was 41%. AQP4-ab was only detected in NMOsd patients and in none of the MSON, CRION and SION patients. Visual acuity (VA) baseline was poor (68%) and 100% of these patients were associated with worse VA outcome as VA of counting fingers only at 6 months with a median time of follow-up of 3.30 (±1.61) years. VA severity is not associated with serological status and no correlation was found between serological status and number of ON relapses. However, 31% of AQP4-ab negative patients developed relapses ON, 40.9% bilateral ON, 18.18% longitudinally extensive transverse myelitis and 75% of CRION patients were associated with better VA outcome
(VA of 20/30 to 20/59).
Conclusion: We emphasize the high specificity of AQP4-ab to distinguish patients with a complete clinical diagnosis of NMO/NMOsd from those with other etiologies. All of patients with VA baseline poor were associated with VA counting finger only at follow-up. AQP4-ab status is not associated with the number of ON relapses and severity disease as has been previously shown in other countries.
Disclosure: nothing to disclose
Abstract: P917
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: Severe isolated, bilateral and/or recurrent optic neuritis (ON) may herald neuromyelitis optica spectrum disorders (NMOsd). However, a broad range of etiologies can be observed. Thus, establishing the correct diagnosis can have an impact in terms of disease specific treatment and prognosis.
Objectives: To report the features, differential diagnosis and prognosis of atypical ON patients at onset in an Argentine population.
Methods: Retrospective study that included 22 sequential patients with atypical features of first acute ON inmmune-mediated at onset, without signs concern for systemic disease, who were referred for consideration of NMOsd, multiple sclerosis ON (MSON), chronic relapsing inflammatory ON (CRION), single isolated ON (SION) or any other inflammatory CNS disorders. Aquaporin-4 antibody (AQP4-Ab) was performed in all patients.
Results: AQP4-ab seropositive proportion was 41%. AQP4-ab was only detected in NMOsd patients and in none of the MSON, CRION and SION patients. Visual acuity (VA) baseline was poor (68%) and 100% of these patients were associated with worse VA outcome as VA of counting fingers only at 6 months with a median time of follow-up of 3.30 (±1.61) years. VA severity is not associated with serological status and no correlation was found between serological status and number of ON relapses. However, 31% of AQP4-ab negative patients developed relapses ON, 40.9% bilateral ON, 18.18% longitudinally extensive transverse myelitis and 75% of CRION patients were associated with better VA outcome
(VA of 20/30 to 20/59).
Conclusion: We emphasize the high specificity of AQP4-ab to distinguish patients with a complete clinical diagnosis of NMO/NMOsd from those with other etiologies. All of patients with VA baseline poor were associated with VA counting finger only at follow-up. AQP4-ab status is not associated with the number of ON relapses and severity disease as has been previously shown in other countries.
Disclosure: nothing to disclose