Contributions
Abstract: P906
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Evaluating responsiveness has an important role in the design and interpretation of results and the consequent clinical decisions obtained in the randomized controlled trial studies.
Purpose: To determine the responsiveness of some commonly-used outcome measures of postural performance following balance rehabilitation in patients with Multiple Sclerosis (MS, n=38) and to determine the minimally clinically important difference (MCID) in change score of balance measures that is perceived beneficial from the patient"s perspective.
Method: Postural performance measures were evaluated at baseline (pre-intervention) and after 4 weeks balance rehabilitation (post-intervention) using a standardized test protocol. Moreover, the 7-point global rating scale was completed by the patients at 4 weeks. Laboratory-based measures were center of pressure (COP) parameters. Clinically-based measures were Activities-specific Balance Confidence (ABC), Berg Balance Scale (BBS), Functional Gait Assessment (FGA), 2 Minute Walk (2MW), 10 Meter Timed Walk (10MW) and Timed Up and Go (TUG). To evaluate responsiveness, we calculated the receiver operating characteristics (ROC) and the area under the ROC curve (AUC) with its 95% confidence interval (CI). The optimal cutoff points for the MCID were determined from the point on the upper left hand corner of the ROC curve.
Results: While the change scores were not statistically significant for all COP parameters in all postural conditions, the AUC values for mean velocity and SD velocity were above the cutoff point of 0.50 in all postural conditions. For the clinically-based outcome measures, the AUCS ranged from 0.36 to 0.64, the highest values were found for the ABC, and 2MW, followed by the BBS and 10MW.
Conclusions: Among laboratory-based measures of postural performance, the mean and SD velocity could be considered as responsive measures of static posturagraphy to detect changes following balance rehabilitation. Also, among clinically-based measures of postural performance, the ABC, 2MW, BBS, and 10MW were responsive outcome measures that quantify balance confidence, walking endurance, functional balance, and walking speed in patients with MS undergoing balance rehabilitation.
Key words: Responsiveness, Postural measures, Balance rehabilitation, Multiple sclerosis
Disclosure: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a Research
grant in Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: P906
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Evaluating responsiveness has an important role in the design and interpretation of results and the consequent clinical decisions obtained in the randomized controlled trial studies.
Purpose: To determine the responsiveness of some commonly-used outcome measures of postural performance following balance rehabilitation in patients with Multiple Sclerosis (MS, n=38) and to determine the minimally clinically important difference (MCID) in change score of balance measures that is perceived beneficial from the patient"s perspective.
Method: Postural performance measures were evaluated at baseline (pre-intervention) and after 4 weeks balance rehabilitation (post-intervention) using a standardized test protocol. Moreover, the 7-point global rating scale was completed by the patients at 4 weeks. Laboratory-based measures were center of pressure (COP) parameters. Clinically-based measures were Activities-specific Balance Confidence (ABC), Berg Balance Scale (BBS), Functional Gait Assessment (FGA), 2 Minute Walk (2MW), 10 Meter Timed Walk (10MW) and Timed Up and Go (TUG). To evaluate responsiveness, we calculated the receiver operating characteristics (ROC) and the area under the ROC curve (AUC) with its 95% confidence interval (CI). The optimal cutoff points for the MCID were determined from the point on the upper left hand corner of the ROC curve.
Results: While the change scores were not statistically significant for all COP parameters in all postural conditions, the AUC values for mean velocity and SD velocity were above the cutoff point of 0.50 in all postural conditions. For the clinically-based outcome measures, the AUCS ranged from 0.36 to 0.64, the highest values were found for the ABC, and 2MW, followed by the BBS and 10MW.
Conclusions: Among laboratory-based measures of postural performance, the mean and SD velocity could be considered as responsive measures of static posturagraphy to detect changes following balance rehabilitation. Also, among clinically-based measures of postural performance, the ABC, 2MW, BBS, and 10MW were responsive outcome measures that quantify balance confidence, walking endurance, functional balance, and walking speed in patients with MS undergoing balance rehabilitation.
Key words: Responsiveness, Postural measures, Balance rehabilitation, Multiple sclerosis
Disclosure: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a Research
grant in Mashhad University of Medical Sciences, Mashhad, Iran.