Contributions
Abstract: P900
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Objective: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system (CNS). In this study, we aimed to discuss the possible predisposing factors to atherosclerosis in multiple sclerosis as carotid intima media thickness (CIMT);an early and sensitive indicator for sublinic atherosclerosis and high sensitive C-reactive protein ( hs-CRP) levels; a nonspecific inflammatory sitokine accelerates the formation of atherosclerotic plaque.
Methods: 36 RRMS patients and age-sex matched 34 healthy controls were included to this study. Blood cell counts, cholesterol levels (total cholesterol, LDL, TG, HDL), vitamine D and B12, hs-CRP levels, body mass index (BMI) and CIMT of both groups, EDSS scores, duration of disease, history of smoking were all recorded. The history of other vascular diseases as hypertension, diabetes mellitus, peripheric artery disease and acute relapses were excluded.
Results: 36 RRMS patients (mean age 36.7±7.6) and 34 healthy controls (mean age 34.3±6.4) were included. In patient group, 20 were female (55,6%), 16 were male (44,4%). Control group contained 21 female (61,8%), 13 male (38,2%). There were significant differences between the values of mean IMT in patient groups than controls (p=< 0.001). There were no significant differences between IMT values in smoking (n:23) and non-smoking (n:47) groups (p=0.86). There were no significant differences of hs-CRP levels in patient group than controls (p=0.13). 4 controls and 4 patients" (n:8) hs-CRP levels were not achieved due to missing blood samples. There were no significant differences between hs-CRP values and IMT in the remaining 62 participants. Low-medium correlation was found in IMT and hs-CRP and very low correlation was found in IMT and EDSS or duration of disease.
Conclusion: In multiple sclerosis, a systemic effect of an inflammatory process might predominantly affect the CNS, thus early diagnosis of the risk may prevent catastrophic results. We found significant differences between the values of mean IMT in patient groups than controls and this made us to consider that multiple sclerosis patients may have predisposition to atherosclerosis. Further investigation in a large MS population is still needed.
Disclosure: Burcu Yuksel: Nothing to disclose
Pinar Koc: Nothing to disclose
Fatma Kurtulus: Nothing to disclose
Eylem Ozaydın Goksu: Nothing to disclose
Ertan Karaçay: Nothing to disclose
Yesim Cekin: Nothing to disclose
Yasemin Bicer Gomceli: Nothing to disclose
Abstract: P900
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Objective: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system (CNS). In this study, we aimed to discuss the possible predisposing factors to atherosclerosis in multiple sclerosis as carotid intima media thickness (CIMT);an early and sensitive indicator for sublinic atherosclerosis and high sensitive C-reactive protein ( hs-CRP) levels; a nonspecific inflammatory sitokine accelerates the formation of atherosclerotic plaque.
Methods: 36 RRMS patients and age-sex matched 34 healthy controls were included to this study. Blood cell counts, cholesterol levels (total cholesterol, LDL, TG, HDL), vitamine D and B12, hs-CRP levels, body mass index (BMI) and CIMT of both groups, EDSS scores, duration of disease, history of smoking were all recorded. The history of other vascular diseases as hypertension, diabetes mellitus, peripheric artery disease and acute relapses were excluded.
Results: 36 RRMS patients (mean age 36.7±7.6) and 34 healthy controls (mean age 34.3±6.4) were included. In patient group, 20 were female (55,6%), 16 were male (44,4%). Control group contained 21 female (61,8%), 13 male (38,2%). There were significant differences between the values of mean IMT in patient groups than controls (p=< 0.001). There were no significant differences between IMT values in smoking (n:23) and non-smoking (n:47) groups (p=0.86). There were no significant differences of hs-CRP levels in patient group than controls (p=0.13). 4 controls and 4 patients" (n:8) hs-CRP levels were not achieved due to missing blood samples. There were no significant differences between hs-CRP values and IMT in the remaining 62 participants. Low-medium correlation was found in IMT and hs-CRP and very low correlation was found in IMT and EDSS or duration of disease.
Conclusion: In multiple sclerosis, a systemic effect of an inflammatory process might predominantly affect the CNS, thus early diagnosis of the risk may prevent catastrophic results. We found significant differences between the values of mean IMT in patient groups than controls and this made us to consider that multiple sclerosis patients may have predisposition to atherosclerosis. Further investigation in a large MS population is still needed.
Disclosure: Burcu Yuksel: Nothing to disclose
Pinar Koc: Nothing to disclose
Fatma Kurtulus: Nothing to disclose
Eylem Ozaydın Goksu: Nothing to disclose
Ertan Karaçay: Nothing to disclose
Yesim Cekin: Nothing to disclose
Yasemin Bicer Gomceli: Nothing to disclose