Contributions
Abstract: P898
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Objective: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system (CNS). Inflammation episodes limited to CNS result in neurological symptoms that partly or completely improve. Platelets play an important role in the pathogenesis of atherosclerosis, also mean platelet volume (MPV) reflects inflammation. MS patients may have an increased risk of atherosclerotic diseases owing to reduced physical activity, smoking, use of glucocorticoids for acute relapses. No data have been reported on the relationship between MPV and risk of atherosclerosis in relapsing remitting MS (RRMS) patients.
Methods: Blood samples of 36 RRMS patients, age-sex matched 34 healthy controls (white blood cell count, thrombocyte count, MPV, neutrophil lymphocyte ratio, platelet lymphocyte ratio), EDSS, duration of disease were recorded. The history of other vascular diseases as hypertension, diabetes mellitus, peripheric artery disease and acute relapses were excluded.
Results: 36 RRMS patients (mean age 36.7±7.6) and 34 healthy controls (mean age 34.3±6.4) were included. In patient group, 20 were female (55,6%), 16 were male (44,4%). Control group contained 21 female (61,8%), 13 male (38,2%). There were significant differences between the values of MPV in patient groups than controls (p=0,04). There were no significant differences between neutrophil lymphocyte ratio or platelet lymphocyte ratio in patient groups than controls (p=0,65; p=0,31, respectively)
Conclusion: We aimed to suggest a simple tool to predict atherosclerosis risk in young RRMS patients. Elevated MPV values were found to be highly associated with atherosclerotic disease in recent studies. In multiple sclerosis, a systemic effect of an inflammatory process might predominantly affect the CNS, thus early diagnosis of the risk may prevent catastrophic results. Although a significant difference between the values of MPV in patient groups than controls was found in our study, further investigation in a large MS population is still needed to assess the definite risk of atherosclerosis.
Disclosure: Burcu Yuksel: Nothing to disclose
Eylem Ozaydın Goksu: Nothing to disclose
Pınar Koc: Nothing to disclose
Fatma Kurtulus: Nothing to disclose
Ertan Karacay: Nothing to disclose
Yeşim Cekin: Nothing to disclose
Yasemin Bicer Gomceli: Nothing to disclose
Abstract: P898
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Objective: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system (CNS). Inflammation episodes limited to CNS result in neurological symptoms that partly or completely improve. Platelets play an important role in the pathogenesis of atherosclerosis, also mean platelet volume (MPV) reflects inflammation. MS patients may have an increased risk of atherosclerotic diseases owing to reduced physical activity, smoking, use of glucocorticoids for acute relapses. No data have been reported on the relationship between MPV and risk of atherosclerosis in relapsing remitting MS (RRMS) patients.
Methods: Blood samples of 36 RRMS patients, age-sex matched 34 healthy controls (white blood cell count, thrombocyte count, MPV, neutrophil lymphocyte ratio, platelet lymphocyte ratio), EDSS, duration of disease were recorded. The history of other vascular diseases as hypertension, diabetes mellitus, peripheric artery disease and acute relapses were excluded.
Results: 36 RRMS patients (mean age 36.7±7.6) and 34 healthy controls (mean age 34.3±6.4) were included. In patient group, 20 were female (55,6%), 16 were male (44,4%). Control group contained 21 female (61,8%), 13 male (38,2%). There were significant differences between the values of MPV in patient groups than controls (p=0,04). There were no significant differences between neutrophil lymphocyte ratio or platelet lymphocyte ratio in patient groups than controls (p=0,65; p=0,31, respectively)
Conclusion: We aimed to suggest a simple tool to predict atherosclerosis risk in young RRMS patients. Elevated MPV values were found to be highly associated with atherosclerotic disease in recent studies. In multiple sclerosis, a systemic effect of an inflammatory process might predominantly affect the CNS, thus early diagnosis of the risk may prevent catastrophic results. Although a significant difference between the values of MPV in patient groups than controls was found in our study, further investigation in a large MS population is still needed to assess the definite risk of atherosclerosis.
Disclosure: Burcu Yuksel: Nothing to disclose
Eylem Ozaydın Goksu: Nothing to disclose
Pınar Koc: Nothing to disclose
Fatma Kurtulus: Nothing to disclose
Ertan Karacay: Nothing to disclose
Yeşim Cekin: Nothing to disclose
Yasemin Bicer Gomceli: Nothing to disclose