Contributions
Abstract: P894
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) that may lead to permanent neurological and visual impairment. Optic nerve provide a useful clinical model to study these characteristics and could be used to measure and monitor the pathology of the disease process
Nowadays, we have observed the emergence of ultrasonography like a novel technique to study this structure. It allows assessment the thickness of the optic nerve through the orbit.
Objective: To assess difference between optic nerve thickness of MS pantients and healthy subjects.
Methods: We performed a case-control study. In order to perform the sonography, patients may lead in supine position and eyes may be closed and relaxed. We used the lowest power possible to achquieve a great image. In a longitudinal view of the nerve, we did three measures with meningeal sheaths at 3 mm of the papilla. Subsequently we used the average. ROC (Receiver Operating Characteristic) was done to identify a cut-off point.
Results: We performed ultrasounds in 63 MS patients and 11 healthy subjets. 43 of 63 patients were women and mean age at diagnosis was 35,37 years. Mean duration of disease was 8.03 years. 85,74% of the patients were relapsing phenotypes, and the rest of them, were progressive. Mean EDSS was 2.71. Mean diameter of right optic nerve was 4.54 mm and 4.63mm for left eye. In healthy subjets, these measures were 5,74 mm for right eye and 5.66 mm for left one. COR showed that values above 5.20mm had a sensitivity of 91% and a specificity of 75% to identify a subject into the healthy group. Lower values identified patients with a sensitivity of 73% and specificity of 95%. Positive predictive value was 62% and negative predictive value was 99%.
Discussion: Optic nerve thickness measured by ultrasounds allows differentiate between healthy subjets and MS patients It is a simple, fast and safe technique that can be performed by neurologist.
Disclosure: Nothing to disclose
Abstract: P894
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) that may lead to permanent neurological and visual impairment. Optic nerve provide a useful clinical model to study these characteristics and could be used to measure and monitor the pathology of the disease process
Nowadays, we have observed the emergence of ultrasonography like a novel technique to study this structure. It allows assessment the thickness of the optic nerve through the orbit.
Objective: To assess difference between optic nerve thickness of MS pantients and healthy subjects.
Methods: We performed a case-control study. In order to perform the sonography, patients may lead in supine position and eyes may be closed and relaxed. We used the lowest power possible to achquieve a great image. In a longitudinal view of the nerve, we did three measures with meningeal sheaths at 3 mm of the papilla. Subsequently we used the average. ROC (Receiver Operating Characteristic) was done to identify a cut-off point.
Results: We performed ultrasounds in 63 MS patients and 11 healthy subjets. 43 of 63 patients were women and mean age at diagnosis was 35,37 years. Mean duration of disease was 8.03 years. 85,74% of the patients were relapsing phenotypes, and the rest of them, were progressive. Mean EDSS was 2.71. Mean diameter of right optic nerve was 4.54 mm and 4.63mm for left eye. In healthy subjets, these measures were 5,74 mm for right eye and 5.66 mm for left one. COR showed that values above 5.20mm had a sensitivity of 91% and a specificity of 75% to identify a subject into the healthy group. Lower values identified patients with a sensitivity of 73% and specificity of 95%. Positive predictive value was 62% and negative predictive value was 99%.
Discussion: Optic nerve thickness measured by ultrasounds allows differentiate between healthy subjets and MS patients It is a simple, fast and safe technique that can be performed by neurologist.
Disclosure: Nothing to disclose