Contributions
Abstract: P888
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS), evaluated by EDSS, relapse and MRI, but none provide cognitive information. Cognitive function impacts: employment, Quality of Life, risk of falling. Traditional measures evaluating cognitive function: employ single score screens, limited availability, and difficult to incorporate into routine care. Computerized cognitive testing can easily incorporate into routine MS care and provide an objective method to screen and track changing disease impact. NeuroTrax computerized cognitive testing (NT) is one digital method to obtain a screening profile in people with MS (PwMS).
Objective: To evaluate the ability of NT identifying the presence of SDMT defined PwMS-cognitive impairment and the degree it correlates with traditional measures.
Methods: Prospective study to determine whether NT scores can predict cognitive impairment as defined by SDMT scores, and correlate NT scores with scores from traditional measures across a variety of cognitive domains.
Results: 46 PwMS and 15 healthy controls. NT- GCS, attention, executive function, memory differentiate cognitive dysfunction in PwMS from normal (defined by SDMT) (p< 0.001), and spatial and speed (p=0.03). NT Global score predicts level of impairment per SDMT: 83% specificity, 58% specificity, >70% positive and negative predictive values. NT cognitive domains correlate with traditional measures: NT-memory vs SRT (p< 0.001, r=.54); NT-attention vs PASAT (p< 0.001, r=.46), SDMT-oral (P< 0.001, r=.64); NT-speed vs PASAT-total (p< 0.003, r=-.38); NT-executive vs DKEFS-CS (p< 0.001, r=.54), FAS (p< 00.01, r=.32), and Animal (p< 0.002, r=.38); NT-verbal vs FAS and Animal (not significant); NT-spatial vs JLO (p< 0.02, r=-.30).
Conclusions: In a preliminary analysis of a larger study, NeuroTrax computerized cognitive testing appears to be useful as a cognitive screen in PwMS. Cognitive impairment in PwMS is common and analysis of cognitive burden of disease by NT could be incorporated into routine care to provide cognitive information that is unique/important and patient centric but not provided by EDSS, relapse rate or MRI findings.
Disclosure: All; nothing to disclose
Abstract: P888
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS), evaluated by EDSS, relapse and MRI, but none provide cognitive information. Cognitive function impacts: employment, Quality of Life, risk of falling. Traditional measures evaluating cognitive function: employ single score screens, limited availability, and difficult to incorporate into routine care. Computerized cognitive testing can easily incorporate into routine MS care and provide an objective method to screen and track changing disease impact. NeuroTrax computerized cognitive testing (NT) is one digital method to obtain a screening profile in people with MS (PwMS).
Objective: To evaluate the ability of NT identifying the presence of SDMT defined PwMS-cognitive impairment and the degree it correlates with traditional measures.
Methods: Prospective study to determine whether NT scores can predict cognitive impairment as defined by SDMT scores, and correlate NT scores with scores from traditional measures across a variety of cognitive domains.
Results: 46 PwMS and 15 healthy controls. NT- GCS, attention, executive function, memory differentiate cognitive dysfunction in PwMS from normal (defined by SDMT) (p< 0.001), and spatial and speed (p=0.03). NT Global score predicts level of impairment per SDMT: 83% specificity, 58% specificity, >70% positive and negative predictive values. NT cognitive domains correlate with traditional measures: NT-memory vs SRT (p< 0.001, r=.54); NT-attention vs PASAT (p< 0.001, r=.46), SDMT-oral (P< 0.001, r=.64); NT-speed vs PASAT-total (p< 0.003, r=-.38); NT-executive vs DKEFS-CS (p< 0.001, r=.54), FAS (p< 00.01, r=.32), and Animal (p< 0.002, r=.38); NT-verbal vs FAS and Animal (not significant); NT-spatial vs JLO (p< 0.02, r=-.30).
Conclusions: In a preliminary analysis of a larger study, NeuroTrax computerized cognitive testing appears to be useful as a cognitive screen in PwMS. Cognitive impairment in PwMS is common and analysis of cognitive burden of disease by NT could be incorporated into routine care to provide cognitive information that is unique/important and patient centric but not provided by EDSS, relapse rate or MRI findings.
Disclosure: All; nothing to disclose