Contributions
Abstract: P886
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS) is a disease measured by use of EDSS, MRI changes and relapse rates. EDSS critical changes and thresholds are primarily driven by changes in walking ability in people with MS (PwMS). EDSS scores strongly correlate with the patient reported outcome (PRO) patient-reported disease progression (PDDS). Functional ability/independence, cognition, fatigue, and depression are important factors to consider when evaluating PwMS disease burden. These factors may impact PwMS independently of EDSS. Despite the fact that EDSS is a universally utilized scale to measure treatment efficacy, cognitive function does not impact EDSS or PDDS. Cognitive function can vary independently of walking ability and is an important aspect of MS disease impact.
Objective: To investigate both the relationship between PDDS and PRO-cognitive function in a PwMS cohort, and to self-reported quality of life (QoL). NARCOMS PRO-cognitive self-assessment questionnaire with higher scores reflecting worse cognitive function.
Methods: PwMS completed standardized PRO questionnaires evaluating disease progression, cognitive function, and a QoL Likert scale. Regression analyses were used to investigate the relationship between PRO-cognitive function and PDDS with PRO-QoL. PDDS groups were defined: low-PDDS (0-1), moderate-PDDS (2-4), and severe-PDDS (>4). The variability of cognitive function was calculated within each PDDS group, and degree overlap of cognitive function was evaluated across PDDS groups.
Results: 785 PwMS (73.5% female, average age = 49.3±11.3). PRO-cognitive function (r=0.39, P=< 0.001) and PDDS (r=0.37, P=< 0.001) both correlated with PRO-QoL. PRO-cognitive function scores however demonstrated marked variability: 85.4% (low-PDDS), 54.6% (moderate-PDDS), and 73.7% (severe-PDDS), and with considerable overlap (55.2%) between adjacent PDDS-groups, and between extreme PDDS-groups (66.1%).
Conclusions: Cognitive function and PDDS are both PRO-scales that impact and relate to PRO-QoL. PDDS despite widespread use and acceptance is a PRO-scale, like EDSS, is insensitive to PRO-cognitive function. PDDS use as measure of important global disability in PwMS should be reconsidered.
Disclosure: All: nothing to disclose
Abstract: P886
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS) is a disease measured by use of EDSS, MRI changes and relapse rates. EDSS critical changes and thresholds are primarily driven by changes in walking ability in people with MS (PwMS). EDSS scores strongly correlate with the patient reported outcome (PRO) patient-reported disease progression (PDDS). Functional ability/independence, cognition, fatigue, and depression are important factors to consider when evaluating PwMS disease burden. These factors may impact PwMS independently of EDSS. Despite the fact that EDSS is a universally utilized scale to measure treatment efficacy, cognitive function does not impact EDSS or PDDS. Cognitive function can vary independently of walking ability and is an important aspect of MS disease impact.
Objective: To investigate both the relationship between PDDS and PRO-cognitive function in a PwMS cohort, and to self-reported quality of life (QoL). NARCOMS PRO-cognitive self-assessment questionnaire with higher scores reflecting worse cognitive function.
Methods: PwMS completed standardized PRO questionnaires evaluating disease progression, cognitive function, and a QoL Likert scale. Regression analyses were used to investigate the relationship between PRO-cognitive function and PDDS with PRO-QoL. PDDS groups were defined: low-PDDS (0-1), moderate-PDDS (2-4), and severe-PDDS (>4). The variability of cognitive function was calculated within each PDDS group, and degree overlap of cognitive function was evaluated across PDDS groups.
Results: 785 PwMS (73.5% female, average age = 49.3±11.3). PRO-cognitive function (r=0.39, P=< 0.001) and PDDS (r=0.37, P=< 0.001) both correlated with PRO-QoL. PRO-cognitive function scores however demonstrated marked variability: 85.4% (low-PDDS), 54.6% (moderate-PDDS), and 73.7% (severe-PDDS), and with considerable overlap (55.2%) between adjacent PDDS-groups, and between extreme PDDS-groups (66.1%).
Conclusions: Cognitive function and PDDS are both PRO-scales that impact and relate to PRO-QoL. PDDS despite widespread use and acceptance is a PRO-scale, like EDSS, is insensitive to PRO-cognitive function. PDDS use as measure of important global disability in PwMS should be reconsidered.
Disclosure: All: nothing to disclose