Contributions
Abstract: P866
Type: Poster
Abstract Category: Clinical aspects of MS - MS symptoms
Background: Multiple Sclerosis (MS) impacts cognition, and patient reported fatigue and depression in a complicated manner that is dynamic and evolves. Most prior studies of the association between subjective cognitive fatigue, depression and objective cognitive dysfunction in patients with MS (PwMS) were cross sectional, thus precluding causal inference.
Objective: To explore how subjective patient reported outcomes (PRO) of cognitive fatigue and depression change over time relate to changes in cognitive function in a large cohort of PwMS.
Methods: PwMS completed a standardized computerized cognitive assessment battery (NeuroTrax) with analysis of age- and education-adjusted cognitive domain scores (memory, executive function, visual spatial, verbal function, attention, information processing, motor skills) and completed PRO metrics in the course of routine clinical care. Cognitive fatigue impact (cognitive subscale of the Modified Fatigue Impact Scale) and depression (Beck Depression Inventory questionnaires) were evaluated respectively. Analysis was repeated after a time interval of 2-53 months, for each patient.
Results: 369 test-retest pairs from 282 PwMS [Female: 220 (78%0, EDSS 2.6±1.9, Education years: 15±2.8]. Both subjective cognitive fatigue and depression were significantly and negatively correlated with the same cognitive domains: memory, executive function, attention, information processing and motor function. Therefore, a fatigue and depression sensitive global cognitive score (FDS-GCS) was defined as the average of these sub-scores. Change in depression was significantly and negatively associated with change in FDS-GCS (r=-0.14, P=0.006) but change in subjective cognitive fatigue was not associated with FDS-GCS change. Change in depression explained only 2% of the variance of change in cognitive scores.
Conclusion: PwMS-PRO Depression could account for only a small degree of the variance in cognitive scores evolution over time. Changes in cognitive scores of PwMS over time, as assessed by NeuroTrax computerized battery, should not be generally ascribed to changes in depression or to changes in fatigue.
Disclosure: Glen Doniger is an employee of NeuroTrax Corporation
Abstract: P866
Type: Poster
Abstract Category: Clinical aspects of MS - MS symptoms
Background: Multiple Sclerosis (MS) impacts cognition, and patient reported fatigue and depression in a complicated manner that is dynamic and evolves. Most prior studies of the association between subjective cognitive fatigue, depression and objective cognitive dysfunction in patients with MS (PwMS) were cross sectional, thus precluding causal inference.
Objective: To explore how subjective patient reported outcomes (PRO) of cognitive fatigue and depression change over time relate to changes in cognitive function in a large cohort of PwMS.
Methods: PwMS completed a standardized computerized cognitive assessment battery (NeuroTrax) with analysis of age- and education-adjusted cognitive domain scores (memory, executive function, visual spatial, verbal function, attention, information processing, motor skills) and completed PRO metrics in the course of routine clinical care. Cognitive fatigue impact (cognitive subscale of the Modified Fatigue Impact Scale) and depression (Beck Depression Inventory questionnaires) were evaluated respectively. Analysis was repeated after a time interval of 2-53 months, for each patient.
Results: 369 test-retest pairs from 282 PwMS [Female: 220 (78%0, EDSS 2.6±1.9, Education years: 15±2.8]. Both subjective cognitive fatigue and depression were significantly and negatively correlated with the same cognitive domains: memory, executive function, attention, information processing and motor function. Therefore, a fatigue and depression sensitive global cognitive score (FDS-GCS) was defined as the average of these sub-scores. Change in depression was significantly and negatively associated with change in FDS-GCS (r=-0.14, P=0.006) but change in subjective cognitive fatigue was not associated with FDS-GCS change. Change in depression explained only 2% of the variance of change in cognitive scores.
Conclusion: PwMS-PRO Depression could account for only a small degree of the variance in cognitive scores evolution over time. Changes in cognitive scores of PwMS over time, as assessed by NeuroTrax computerized battery, should not be generally ascribed to changes in depression or to changes in fatigue.
Disclosure: Glen Doniger is an employee of NeuroTrax Corporation