Abstract: P821
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: Neuromyelitis Optica Spectrum Disorders (NMOSD) is a severe inflammatory disease of the central nervous system. Diagnosis awareness has increased in recent times; however, information of NMOSD characteristics in Latin America is still sparse.
Objective: To report clinical and epidemiological data of NMOSD patients in Argentina.
Methods: We retrospectively reviewed the medical records of patients affected by NMOSD, according to 2015 revised criteria, attending Ramos Mejia Hospital in Buenos Aires, Argentina from January 2007 to April 2016.
Results: We recruited 61 patients (46 females). Out of 51/61 patients tested, 32 (63 %) were AQP4-IgG (+). Mean age at onset and disease duration was 33 (range 4-58) years and 7.6 (range 0.5-22) years respectively. At presentation, 33 patients (54 %) had optic neuritis (ON), 20 (32.7%) transverse myelitis (TM) and 8 (13 %) simultaneous TM and ON. The Annualized Relapse Rate (ARR) was 0.7. The female to male ratio was 1.4/1 for AQP4-IgG (-) and 5.2/1 for AQP4-IgG (+) patients. Association with other autoimmune diseases occurred in 20/61 (32.7%) patients, 59 % were AQP4-IgG (+). 11/61 patients were examined for psychiatric comorbidities; 6/11 showed depression, 2/11 bipolar disorder and 4/11 suicidality. Brain MRI abnormalities were present in 23 NMOSD patients (37.7 %). 13/61 (21.3%) patients have a late onset (≥ 40 years).
Conclusions: This is the largest cohort of NMOSD patients described in Argentina. 63% of patients were seropositive for AQP4-IgG antibodies. We showed a female to male ratio higher in AQP4-IgG seropositive patients. ON was the most common presentation of the disease. 32.7% of patients had other autoimmune disease associated. We also demonstrate a high rate of psychiatric comorbidities.
Disclosure: Pita C: nothing to disclose.
Fernández V: nothing to disclose.
Garino E: nothing to disclose.
Melamud L: nothing to disclose.
Villa A: nothing to disclose.
Abstract: P821
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: Neuromyelitis Optica Spectrum Disorders (NMOSD) is a severe inflammatory disease of the central nervous system. Diagnosis awareness has increased in recent times; however, information of NMOSD characteristics in Latin America is still sparse.
Objective: To report clinical and epidemiological data of NMOSD patients in Argentina.
Methods: We retrospectively reviewed the medical records of patients affected by NMOSD, according to 2015 revised criteria, attending Ramos Mejia Hospital in Buenos Aires, Argentina from January 2007 to April 2016.
Results: We recruited 61 patients (46 females). Out of 51/61 patients tested, 32 (63 %) were AQP4-IgG (+). Mean age at onset and disease duration was 33 (range 4-58) years and 7.6 (range 0.5-22) years respectively. At presentation, 33 patients (54 %) had optic neuritis (ON), 20 (32.7%) transverse myelitis (TM) and 8 (13 %) simultaneous TM and ON. The Annualized Relapse Rate (ARR) was 0.7. The female to male ratio was 1.4/1 for AQP4-IgG (-) and 5.2/1 for AQP4-IgG (+) patients. Association with other autoimmune diseases occurred in 20/61 (32.7%) patients, 59 % were AQP4-IgG (+). 11/61 patients were examined for psychiatric comorbidities; 6/11 showed depression, 2/11 bipolar disorder and 4/11 suicidality. Brain MRI abnormalities were present in 23 NMOSD patients (37.7 %). 13/61 (21.3%) patients have a late onset (≥ 40 years).
Conclusions: This is the largest cohort of NMOSD patients described in Argentina. 63% of patients were seropositive for AQP4-IgG antibodies. We showed a female to male ratio higher in AQP4-IgG seropositive patients. ON was the most common presentation of the disease. 32.7% of patients had other autoimmune disease associated. We also demonstrate a high rate of psychiatric comorbidities.
Disclosure: Pita C: nothing to disclose.
Fernández V: nothing to disclose.
Garino E: nothing to disclose.
Melamud L: nothing to disclose.
Villa A: nothing to disclose.