Abstract: P820
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: Neuromyelitis optica spectrum disorders (NMOSD) is a severe inflammatory disease affecting the Central Nervous System (CNS). Awareness of psychiatric comorbidities has increased among neurologists, however there are few reports assessing this issue, and information on psycopathological profile is sparse.
Objective: The objective of the present study is to analyze the psychopathological profile and suicide risk in patients with neuromyelitis optica spectrum disorders NMOSD in an Argentinian cohort.
Methods: 21 patients with NMOSD diagnosed according to 2015 criteria, attending follow-up medical visits at Neuroimmunology Department at Ramos Mejia Hospital in Buenos Aires, between 2006 and 2015 were included. Current depression was assessed using the self-administered Beck Depression Inventory scale (BDI) and psychiatric illness using the MINI International Neuropsychiatric Interview 5.0.0 Spanish version, performed by a psychiatrist. Disability was assessed by EDSS.
Results: We collected data from 21 patients, 76.2% were females, mean age 38.5 years (range 20-58), mean EDSS 3.5 (range 1.0-8.0). Psychiatric comorbidity was present in 9 of 21 patients (42.85%). Using the International Neuropsychiatric Interview, diagnosis of major depressive disorder was performed in 4 patients (19%), bipolar disorder in 2 (9.5%), dysthymic disorder in 2 (9.5%) and anxiety disorder in 1 (4.8%). 6/21 patients (28.6%) had one or more previous suicide attempts. In 7/21 patients current depression was evidentusing BDI, with 4 patients being severe depressed. A direct link between severe depression and major disability was observed.
Conclusions: Our study shows that the prevalence of psychiatric comorbidities in patients with NMOSDis 42.85%. Furthermore, suicide attempts were present in 28.6% of patients. Given the high frequency, it is important to asses associated psychiatric disorders in patients with NMOSD to optimize monitoring and comprehensive treatment of these patients.
Disclosure: Fernández V: nothing to disclose
Pita C: nothing to disclose
Alonso N: nothing to disclose
Melamud L: nothing to disclose
Villa AM: nothing to disclose
Abstract: P820
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: Neuromyelitis optica spectrum disorders (NMOSD) is a severe inflammatory disease affecting the Central Nervous System (CNS). Awareness of psychiatric comorbidities has increased among neurologists, however there are few reports assessing this issue, and information on psycopathological profile is sparse.
Objective: The objective of the present study is to analyze the psychopathological profile and suicide risk in patients with neuromyelitis optica spectrum disorders NMOSD in an Argentinian cohort.
Methods: 21 patients with NMOSD diagnosed according to 2015 criteria, attending follow-up medical visits at Neuroimmunology Department at Ramos Mejia Hospital in Buenos Aires, between 2006 and 2015 were included. Current depression was assessed using the self-administered Beck Depression Inventory scale (BDI) and psychiatric illness using the MINI International Neuropsychiatric Interview 5.0.0 Spanish version, performed by a psychiatrist. Disability was assessed by EDSS.
Results: We collected data from 21 patients, 76.2% were females, mean age 38.5 years (range 20-58), mean EDSS 3.5 (range 1.0-8.0). Psychiatric comorbidity was present in 9 of 21 patients (42.85%). Using the International Neuropsychiatric Interview, diagnosis of major depressive disorder was performed in 4 patients (19%), bipolar disorder in 2 (9.5%), dysthymic disorder in 2 (9.5%) and anxiety disorder in 1 (4.8%). 6/21 patients (28.6%) had one or more previous suicide attempts. In 7/21 patients current depression was evidentusing BDI, with 4 patients being severe depressed. A direct link between severe depression and major disability was observed.
Conclusions: Our study shows that the prevalence of psychiatric comorbidities in patients with NMOSDis 42.85%. Furthermore, suicide attempts were present in 28.6% of patients. Given the high frequency, it is important to asses associated psychiatric disorders in patients with NMOSD to optimize monitoring and comprehensive treatment of these patients.
Disclosure: Fernández V: nothing to disclose
Pita C: nothing to disclose
Alonso N: nothing to disclose
Melamud L: nothing to disclose
Villa AM: nothing to disclose