Contributions
Abstract: P815
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: Neuromyelitis Optica (NMO) is a demyelinating autoimmune disease classically defined by the presence of optic neuritis and transverse myelitis. However, since the discovery of the diagnostic biomarker aquaporin-4 immunoglobulin G antibody (AQP-4 IgG), a more diverse set of symptoms and imaging is being recognized as part of the NMO disease spectrum. Most prominently, the presence of abnormal brain magnetic resonance imaging (MRI) is now considered a diagnostic component of NMO.
Aim: We aim to characterize the radiographic features of NMO on brain MRI and understand the impact of brain imaging abnormalities on functional outcomes within the Columbia University Medical Center (CUMC) patient population.
Methods: We performed a retrospective data collection to obtain clinical information and review imaging of patients diagnosed with NMO using the 2015 revised diagnostic criteria for NMO spectrum disorder. We then used the Expanded Disability Status Scale (EDSS) to compare the functional status of those with and without brain parenchymal abnormalities.
Results: There were 31 patients with imaging available for review. 29 (90%) had spinal cord lesions, with an average lesion length of 3.6 vertebral levels, and 10 (31%) had optic nerve lesions. 25 (78%) had parenchymal findings, most prominently non-specific cerebral fluid attenuation inversion recovery (FLAIR) hyperintensities (15) and periventricular hyperintensities (13), and less prominently infratentorial (8) and corpus callosum (8) involvement. Interestingly, 4 patients had multi-lobe confluent lesions. Those with parenchymal abnormalities of any kind also had a worse average EDSS (6.0) compared to those without (3.3).
Conclusions: Though spinal cord and optic nerve involvement remain the most common features of NMO, parenchymal involvement is an increasingly recognized component of the disease, and there is an association between parenchymal involvement and worse functional outcome within our patient population.
Disclosure: Chu-Yueh Guo: nothing to disclose
Claire S. Riley: nothing to disclose
Abstract: P815
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: Neuromyelitis Optica (NMO) is a demyelinating autoimmune disease classically defined by the presence of optic neuritis and transverse myelitis. However, since the discovery of the diagnostic biomarker aquaporin-4 immunoglobulin G antibody (AQP-4 IgG), a more diverse set of symptoms and imaging is being recognized as part of the NMO disease spectrum. Most prominently, the presence of abnormal brain magnetic resonance imaging (MRI) is now considered a diagnostic component of NMO.
Aim: We aim to characterize the radiographic features of NMO on brain MRI and understand the impact of brain imaging abnormalities on functional outcomes within the Columbia University Medical Center (CUMC) patient population.
Methods: We performed a retrospective data collection to obtain clinical information and review imaging of patients diagnosed with NMO using the 2015 revised diagnostic criteria for NMO spectrum disorder. We then used the Expanded Disability Status Scale (EDSS) to compare the functional status of those with and without brain parenchymal abnormalities.
Results: There were 31 patients with imaging available for review. 29 (90%) had spinal cord lesions, with an average lesion length of 3.6 vertebral levels, and 10 (31%) had optic nerve lesions. 25 (78%) had parenchymal findings, most prominently non-specific cerebral fluid attenuation inversion recovery (FLAIR) hyperintensities (15) and periventricular hyperintensities (13), and less prominently infratentorial (8) and corpus callosum (8) involvement. Interestingly, 4 patients had multi-lobe confluent lesions. Those with parenchymal abnormalities of any kind also had a worse average EDSS (6.0) compared to those without (3.3).
Conclusions: Though spinal cord and optic nerve involvement remain the most common features of NMO, parenchymal involvement is an increasingly recognized component of the disease, and there is an association between parenchymal involvement and worse functional outcome within our patient population.
Disclosure: Chu-Yueh Guo: nothing to disclose
Claire S. Riley: nothing to disclose