Contributions
Abstract: P810
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Neuromyelitis optica(NMO) is an immune-mediated, usually relapsing, inflammatory disease characterized by severe attacks of optic neuritis(ON) and myelitis.Although most of the NMO patients are female on childbearing age, there is still inefficient data regarding with the pregnancy outcomes in NMO patients and pregnancy related attacks.
Objective: To reveal the relation between Neuromyelitis Optica Spectrum Disorder(NMOSD) and pregnancy.
Methods: A total of 29 female with NMOSD whom were followed with different centers in Turkey were enrolled.Inclusion criteria was to have at least one conception.The demographic and clinical features of patients were documented. A questionnaire including the number of conception, the number of spontaneous abortion and medical abortion before and after onset of NMO were asked and the outcome of pregnancy and fetus was recorded.A total of fifty-eight conception was evaluated.The number of relapses during each trimester of pregnancy and postpartum period were also assessed.
Results: The mean age of the patients was 42.4(range:24-59).The average age at first pregnancy was 23.2 (range:15-34).The total fertility rate was found to be 1.75 in NMO group whereas 2.07 in general Turkish population according to official reports.
The number of conception before onset of NMO was 49 and 9 after the diagnosis.Regarding the outcome of the conception, six spontaneous abortion was reported prior to diagnosis(12.24%) and one(11%) after the diagnosis, which was lower than the general Turkish population(20.5%).
Seven of twenty-nine patients(24.1%) had a relapse in the first pregnancy while six of them occurred on the postpartum period(85.7%) and the remaining one was during the third trimester.Eighteen patients had second delivery and only one of them(12.5%) had relapse,which was seen in the second trimester.Five of the patients had third delivery and no relapse was observed.
Conclusion: The conception rate in NMO was found to be lower than the general population. No major congenital anomalies were detected in newborns.Similar with multiple sclerosis, NMO has a negative impact on reproductive attitudes and a higher relapse rate in the post-partum first 3 months.
Disclosure: A.Altintas: She received honoraria, research and travel grants from Teva, Merck Serono, Gen İlac, Bayer Schering, Novartis
U.Uygunoglu: He received honoraria, research and travel grants from Merck Serono, Gen İlac, Novartis
M.Terzi:nothing to disclose
C.Boz: nothing to disclose
S.Saip: He received honoraria and research grants from Merck Serono, Gen İlac, Novartis
M.Koseoglu:nothing to disclose
N.Kale:nothing to disclose
M.Ozturk:nothing to disclose
C.F. Demir: nothing to disclose
A.Soysal: nothing to disclose
M.Ozerden: nothing to disclose
E.O. Dogan:nothing to disclose
S.Z.Ozturk:nothing to disclose
A.Siva: He received honoraria, research and travel grants from Teva, Merck Serono, Gen İlac, Bayer Schering, Novartis, Sanofi Genzyme
Abstract: P810
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Neuromyelitis optica(NMO) is an immune-mediated, usually relapsing, inflammatory disease characterized by severe attacks of optic neuritis(ON) and myelitis.Although most of the NMO patients are female on childbearing age, there is still inefficient data regarding with the pregnancy outcomes in NMO patients and pregnancy related attacks.
Objective: To reveal the relation between Neuromyelitis Optica Spectrum Disorder(NMOSD) and pregnancy.
Methods: A total of 29 female with NMOSD whom were followed with different centers in Turkey were enrolled.Inclusion criteria was to have at least one conception.The demographic and clinical features of patients were documented. A questionnaire including the number of conception, the number of spontaneous abortion and medical abortion before and after onset of NMO were asked and the outcome of pregnancy and fetus was recorded.A total of fifty-eight conception was evaluated.The number of relapses during each trimester of pregnancy and postpartum period were also assessed.
Results: The mean age of the patients was 42.4(range:24-59).The average age at first pregnancy was 23.2 (range:15-34).The total fertility rate was found to be 1.75 in NMO group whereas 2.07 in general Turkish population according to official reports.
The number of conception before onset of NMO was 49 and 9 after the diagnosis.Regarding the outcome of the conception, six spontaneous abortion was reported prior to diagnosis(12.24%) and one(11%) after the diagnosis, which was lower than the general Turkish population(20.5%).
Seven of twenty-nine patients(24.1%) had a relapse in the first pregnancy while six of them occurred on the postpartum period(85.7%) and the remaining one was during the third trimester.Eighteen patients had second delivery and only one of them(12.5%) had relapse,which was seen in the second trimester.Five of the patients had third delivery and no relapse was observed.
Conclusion: The conception rate in NMO was found to be lower than the general population. No major congenital anomalies were detected in newborns.Similar with multiple sclerosis, NMO has a negative impact on reproductive attitudes and a higher relapse rate in the post-partum first 3 months.
Disclosure: A.Altintas: She received honoraria, research and travel grants from Teva, Merck Serono, Gen İlac, Bayer Schering, Novartis
U.Uygunoglu: He received honoraria, research and travel grants from Merck Serono, Gen İlac, Novartis
M.Terzi:nothing to disclose
C.Boz: nothing to disclose
S.Saip: He received honoraria and research grants from Merck Serono, Gen İlac, Novartis
M.Koseoglu:nothing to disclose
N.Kale:nothing to disclose
M.Ozturk:nothing to disclose
C.F. Demir: nothing to disclose
A.Soysal: nothing to disclose
M.Ozerden: nothing to disclose
E.O. Dogan:nothing to disclose
S.Z.Ozturk:nothing to disclose
A.Siva: He received honoraria, research and travel grants from Teva, Merck Serono, Gen İlac, Bayer Schering, Novartis, Sanofi Genzyme