Contributions
Abstract: P809
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) have been recently reported mainly in acute demyelinating encephalomyelitis (ADEM) and optic neuritis (ON) in children and Neuromyelitis Optica spectrum disorders (NMOSD) in adults. Since MOG-Ab related disorders are an emerging entity, the whole spectrum has likely not been completely described.
Objectives: To delineate clinical, laboratory and radiological features in a cohort of MOG-Ab positive patients.
Methods: Twenty four consecutive paediatric (≤16 years old) and adult patients testing positive for MOG-Ab between January 2014 through April 2016 were included. Comprehensive epidemiological, clinical, laboratory and magnetic resonance imaging (MRI) were retrospectively analyzed.
Results: Among the whole cohort, 12 (50%) were paediatric and 50% were men. MOG-Ab related disorders comprised 9 ADEM, 4 NMOSD, 5 monophasic acute myelitis (4 extensive and 1 non-extensive), 5 ON (1 monophasic and 4 relapsing) and one multiple sclerosis (MS). After a median follow-up of 14.83 months (interquartile range, 7.6-69.2), 10 (41.7%) patients presented a relapsing course. Among those with an abnormal brain MRI, 6 (40%) showed specific bilateral thalamic lesions and 5 (33%) in the fourth ventricle (increasing to 71.4% and 50% among the paediatric cohort, respectively). There were no differences between paediatrics and adults patients regarding gender, relapsing course, radiological features or outcome apart of a tendency for encephalopathy as a first clinical presentation in the paediatric group (50% vs 8.1%, respectively p=0.069). We identified unusual presentation in 5 patients: an associated teratoma (n=1), a concomitant HHV-6 myelitis (n=1), an associated neurofribromatosis-1 (n=1), seizures (n=1), and a non-extensive myelitis showing a “patchy pattern” along the whole spinal cord MRI (n=1).
Conclusion: MOG-Ab related disorders shared common clinical and prognostic features but encompasses a spectrum much wider than recently reported.
Disclosure: Cobo-Calvo A: Nothing to disclose
Ruiz A: Nothing to disclose
Anne-Lise P: Nothing to disclose
Marilyne C:Nothing to disclose
Durand-Dubief F: Nothing to disclose
Vukusic S:Nothing to disclose
Desportes V: Nothing to disclose
Marignier R: Nothing to disclose
Abstract: P809
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) have been recently reported mainly in acute demyelinating encephalomyelitis (ADEM) and optic neuritis (ON) in children and Neuromyelitis Optica spectrum disorders (NMOSD) in adults. Since MOG-Ab related disorders are an emerging entity, the whole spectrum has likely not been completely described.
Objectives: To delineate clinical, laboratory and radiological features in a cohort of MOG-Ab positive patients.
Methods: Twenty four consecutive paediatric (≤16 years old) and adult patients testing positive for MOG-Ab between January 2014 through April 2016 were included. Comprehensive epidemiological, clinical, laboratory and magnetic resonance imaging (MRI) were retrospectively analyzed.
Results: Among the whole cohort, 12 (50%) were paediatric and 50% were men. MOG-Ab related disorders comprised 9 ADEM, 4 NMOSD, 5 monophasic acute myelitis (4 extensive and 1 non-extensive), 5 ON (1 monophasic and 4 relapsing) and one multiple sclerosis (MS). After a median follow-up of 14.83 months (interquartile range, 7.6-69.2), 10 (41.7%) patients presented a relapsing course. Among those with an abnormal brain MRI, 6 (40%) showed specific bilateral thalamic lesions and 5 (33%) in the fourth ventricle (increasing to 71.4% and 50% among the paediatric cohort, respectively). There were no differences between paediatrics and adults patients regarding gender, relapsing course, radiological features or outcome apart of a tendency for encephalopathy as a first clinical presentation in the paediatric group (50% vs 8.1%, respectively p=0.069). We identified unusual presentation in 5 patients: an associated teratoma (n=1), a concomitant HHV-6 myelitis (n=1), an associated neurofribromatosis-1 (n=1), seizures (n=1), and a non-extensive myelitis showing a “patchy pattern” along the whole spinal cord MRI (n=1).
Conclusion: MOG-Ab related disorders shared common clinical and prognostic features but encompasses a spectrum much wider than recently reported.
Disclosure: Cobo-Calvo A: Nothing to disclose
Ruiz A: Nothing to disclose
Anne-Lise P: Nothing to disclose
Marilyne C:Nothing to disclose
Durand-Dubief F: Nothing to disclose
Vukusic S:Nothing to disclose
Desportes V: Nothing to disclose
Marignier R: Nothing to disclose