Contributions
Abstract: P804
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Aims of the study: To assess impact of the 2015 criteria for neuromyelitis optica spectrum disorder (NMOSD) diagnosis and the delay to obtain it. To evaluate indications and efficiency of serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) assessment. To describe seronegative patients features.
Methods: We performed a monocentric retrospective study. We included all patients tested for AQP4-IgG in Rouen university hospital between the 17th january 2011 and the 20th june 2014. All samples were analysed in Lyon Hospital. Clinical, biological, radiological features, final diagnosis and the delay to obtain it, were analysed.
Results: 101 patients were included. The new NMOSD criteria facilitated the diagnosis for 8 patients (42%) including 4 seropositive patients with monofocal symptoms (21%). Diagnosis delay from the first examination was significantly shorter with the new criteria (18,7 months) than with the 2006 one´s (39,3 months) (p=0,02). In our study, seropositive and seronegative patients did not differ significantly regarding the clinical, biological and imaging features.
Conclusion: The new NMOSD diagnosis criteria facilitate earlier and more accurate diagnosis. The AQP4-IgG allows NMOSD diagnosis whereas the symptoms are monofocal.
Disclosure: nothing to disclose
Abstract: P804
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Aims of the study: To assess impact of the 2015 criteria for neuromyelitis optica spectrum disorder (NMOSD) diagnosis and the delay to obtain it. To evaluate indications and efficiency of serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) assessment. To describe seronegative patients features.
Methods: We performed a monocentric retrospective study. We included all patients tested for AQP4-IgG in Rouen university hospital between the 17th january 2011 and the 20th june 2014. All samples were analysed in Lyon Hospital. Clinical, biological, radiological features, final diagnosis and the delay to obtain it, were analysed.
Results: 101 patients were included. The new NMOSD criteria facilitated the diagnosis for 8 patients (42%) including 4 seropositive patients with monofocal symptoms (21%). Diagnosis delay from the first examination was significantly shorter with the new criteria (18,7 months) than with the 2006 one´s (39,3 months) (p=0,02). In our study, seropositive and seronegative patients did not differ significantly regarding the clinical, biological and imaging features.
Conclusion: The new NMOSD diagnosis criteria facilitate earlier and more accurate diagnosis. The AQP4-IgG allows NMOSD diagnosis whereas the symptoms are monofocal.
Disclosure: nothing to disclose