Abstract: P802
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background and goals: Recently, several characteristics of optic nerve MRI suggesting NMOSD in patients without AQP4-IgG or with unknown AQP4-IgG status were reported by the international consensus group. In this study, we aimed to evaluate the optic nerve MRI pattern in patients with first-ever optic neuritis.
Methods: Patients with first-ever optic neuritis were included who visited in Seoul National University Hospital and Seoul National University Boramae Hospital from March 2008 to May 2015. As those institutes are tertiary and referral hospital, we enrolled patients when they were examined and treated in other hospital and soon after referred with medical records. We analyzed data of optic nerve MRI, brain MRI, and ophthalmic examinations.
Results: Total 92 patients´ data were analyzed. Numbers of female were 62 (67.4%) and bilateral eye involvements were 19 (20.7%). Mean age of onset was 41.8 year-old. Mean time of follow-up was 24.3 months. Results of AQP4-IgG test were available in 66 patients and were positive in 14 (15.2%). Number of patients diagnosed with NMOSD with AQP4-IgG was 11 (12.0%), without AQP4-IgG was 3 (3.3%), and NMO by 2006 criteria was 5 (5.4%). Optic nerve MRI patterns known to be specific in NMOSD were not significantly seen in patients with NMOSD/NMO or not different according AQP4-IgG status: lesion extending over > 1/2 optic nerve length, involving optic chiasm or posterior segment.
Conclusion: Optic nerve MRI were not characteristic in patients with NMOSD/NMO. Diagnosis of NMOSD in Korea seems to be dependent highly in AQP4-IgG status rather than optic nerve MRI.
Disclosure: Nothing to disclose
Abstract: P802
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background and goals: Recently, several characteristics of optic nerve MRI suggesting NMOSD in patients without AQP4-IgG or with unknown AQP4-IgG status were reported by the international consensus group. In this study, we aimed to evaluate the optic nerve MRI pattern in patients with first-ever optic neuritis.
Methods: Patients with first-ever optic neuritis were included who visited in Seoul National University Hospital and Seoul National University Boramae Hospital from March 2008 to May 2015. As those institutes are tertiary and referral hospital, we enrolled patients when they were examined and treated in other hospital and soon after referred with medical records. We analyzed data of optic nerve MRI, brain MRI, and ophthalmic examinations.
Results: Total 92 patients´ data were analyzed. Numbers of female were 62 (67.4%) and bilateral eye involvements were 19 (20.7%). Mean age of onset was 41.8 year-old. Mean time of follow-up was 24.3 months. Results of AQP4-IgG test were available in 66 patients and were positive in 14 (15.2%). Number of patients diagnosed with NMOSD with AQP4-IgG was 11 (12.0%), without AQP4-IgG was 3 (3.3%), and NMO by 2006 criteria was 5 (5.4%). Optic nerve MRI patterns known to be specific in NMOSD were not significantly seen in patients with NMOSD/NMO or not different according AQP4-IgG status: lesion extending over > 1/2 optic nerve length, involving optic chiasm or posterior segment.
Conclusion: Optic nerve MRI were not characteristic in patients with NMOSD/NMO. Diagnosis of NMOSD in Korea seems to be dependent highly in AQP4-IgG status rather than optic nerve MRI.
Disclosure: Nothing to disclose