Contributions
Abstract: P771
Type: Poster
Abstract Category: Therapy - symptomatic - Quality of life
Background: We recently developed a short version of Multiple Sclerosis Quality Of Life-54 (MSQOL-54) using factor analysis and item response theory [Rosato et al., Plos ONE 2016]. The short version, named MSQOL-29 (25 items grouped in 7 subscales, plus 4 single items) is also available in electronic, self-administered form, with automatic scoring (eMSQOL-29).
Objectives: To prospectively assess the clinical and metric properties of the eMSQOL-29.
Methods: Patients from 5 Italian MS centers completed (in citation order) eMSQOL-29, Hospital Anxiety and Depression Scale (HADS), Functional Assessment of Multiple Sclerosis (FAMS), and European Quality of life Dimensions-3L (EQ-5D-3L). The neurologist administered the Extended Disability Status Scale (EDSS), the symbol digit modality test (SDMT) and recorded patient general and clinical information. Correlations were assessed using Pearson"s r. Cronbach"s alpha and confirmative factor analysis (CFA) of MSQOL-29 subscales were also performed.
Results: Between September 2015 and April 2016, 588 MS patients were assessed (mean age 44.1 years; 68% women). Median EDSS score was 2.0 (range 0-9.0), mean SDMT was 47.5 (SD 14.9, 46.9% had score < 49). Mean FAMS score was 125.3 (SD 26.8); mean HADS-Anxiety score was 6.0 (SD 4.0, 27.6% had score >8), mean HADS-Depression score was 4.2 (SD 3.7, 15.1% had score >8); and mean EQ-5D-3L score was 0.85 (SD 0.17).
Three of the 4 Sexual Function items were preceded by a filter question, and were filtered out in 276 patients (47%). Of the remaining items, missing replies ranged from 2.4% (item 1) to 8% (item 29). Subscales with maximum score >10% were Physical Function, Sexual Function, Cognitive Function, Pain and Health Distress. No subscales had minimum score >10%. Cronbach"s alpha ranged from 0.78 (Sexual Function) to 0.96 (Physical Function). CFA of eMSQOL-29 subscales showed good overall fit (RMSEA 0.032; CFI 0.99; SRMR 0.042). Correlations between the four eMSQOL-29 and FAMS subscales addressing similar domains ranged from 0.62 (p< 0.001) to 0.85 (p< 0.001); correlation of eMSQOL-29 Emotional Wellbeing with HADS-Anxiety was -0.57 (p< 0.001), with HADS-Depression was -0.54 (p< 0.001); correlation of eMSQOL-29 Cognitive Function with SDMT was 0.29 (p< 0.001).
Conclusions: eMSQOL-29 showed good internal consistency, factor structure, and no floor effect, while most subscales had some ceiling effect. Concurrent validity was good except for low correlation for cognitive domain.
Disclosure:
Funding: This study was supported by the Fondazione Italiana Sclerosi Multipla (FISM, www.aism.it, grant No. 2013/R/20 to RR).
Conflict of interest: The authors have nothing to disclose.
Abstract: P771
Type: Poster
Abstract Category: Therapy - symptomatic - Quality of life
Background: We recently developed a short version of Multiple Sclerosis Quality Of Life-54 (MSQOL-54) using factor analysis and item response theory [Rosato et al., Plos ONE 2016]. The short version, named MSQOL-29 (25 items grouped in 7 subscales, plus 4 single items) is also available in electronic, self-administered form, with automatic scoring (eMSQOL-29).
Objectives: To prospectively assess the clinical and metric properties of the eMSQOL-29.
Methods: Patients from 5 Italian MS centers completed (in citation order) eMSQOL-29, Hospital Anxiety and Depression Scale (HADS), Functional Assessment of Multiple Sclerosis (FAMS), and European Quality of life Dimensions-3L (EQ-5D-3L). The neurologist administered the Extended Disability Status Scale (EDSS), the symbol digit modality test (SDMT) and recorded patient general and clinical information. Correlations were assessed using Pearson"s r. Cronbach"s alpha and confirmative factor analysis (CFA) of MSQOL-29 subscales were also performed.
Results: Between September 2015 and April 2016, 588 MS patients were assessed (mean age 44.1 years; 68% women). Median EDSS score was 2.0 (range 0-9.0), mean SDMT was 47.5 (SD 14.9, 46.9% had score < 49). Mean FAMS score was 125.3 (SD 26.8); mean HADS-Anxiety score was 6.0 (SD 4.0, 27.6% had score >8), mean HADS-Depression score was 4.2 (SD 3.7, 15.1% had score >8); and mean EQ-5D-3L score was 0.85 (SD 0.17).
Three of the 4 Sexual Function items were preceded by a filter question, and were filtered out in 276 patients (47%). Of the remaining items, missing replies ranged from 2.4% (item 1) to 8% (item 29). Subscales with maximum score >10% were Physical Function, Sexual Function, Cognitive Function, Pain and Health Distress. No subscales had minimum score >10%. Cronbach"s alpha ranged from 0.78 (Sexual Function) to 0.96 (Physical Function). CFA of eMSQOL-29 subscales showed good overall fit (RMSEA 0.032; CFI 0.99; SRMR 0.042). Correlations between the four eMSQOL-29 and FAMS subscales addressing similar domains ranged from 0.62 (p< 0.001) to 0.85 (p< 0.001); correlation of eMSQOL-29 Emotional Wellbeing with HADS-Anxiety was -0.57 (p< 0.001), with HADS-Depression was -0.54 (p< 0.001); correlation of eMSQOL-29 Cognitive Function with SDMT was 0.29 (p< 0.001).
Conclusions: eMSQOL-29 showed good internal consistency, factor structure, and no floor effect, while most subscales had some ceiling effect. Concurrent validity was good except for low correlation for cognitive domain.
Disclosure:
Funding: This study was supported by the Fondazione Italiana Sclerosi Multipla (FISM, www.aism.it, grant No. 2013/R/20 to RR).
Conflict of interest: The authors have nothing to disclose.