Contributions
Abstract: P770
Type: Poster
Abstract Category: Therapy - symptomatic - Quality of life
Background: Health-Related Quality of Life (HRQoL) is an important patient reported outcome (PRO) in MS disease management. Physical disability and emotional factors were identified as affecting HRQoL of persons with MS (PwMS), while the effects of perceptions were considered only scarcely.
Aims: To assess the effects of physical disability, illness and medication perceptions and emotional factors on the HRQoL of PwMS.
Methods: Pilot study of 66 Relapsing Remitting PwMS treated at our MS Center. Questionnaires assessing HRQoL, demographic data, illness and medicine perceptions, and emotional factors were filled by the participants. Physical disability (EDSS) was evaluated by the treating neurologist. Univariable analysis and Hierarchical Forced Step Regression were performed to assess association of the variables with HRQoL.
Results: Univariable analysis indicated that socio-economic status (SES), EDSS, illness perception, medication perception and emotional factors were significant associated with HRQoL. Hierarchical Forced Step Regression was performed in five steps. The analysis revealed a weak association of SES (β=0.36, p< 0.01, R²model=9.9%) in the demographic step and no significant effect of EDSS in the physical disability step (R²model=12.4%). A strong significant association of illness and medicine perceptions (β=0.36, p< 0.01and β =0.23, p=0.05, respectively, and R²model=29.2%) were found in the perceptions step, in addition to the strong association of the emotional factors anxiety (β =-0.41,
p< 0.01and R² model = 37.1%) and depression (β =-0.486, p=0.02 and R² model =43.0%) shown in the fourth and fifth steps. The addition of emotional factors to the final steps of the model masked the effect of factors significant in the previous steps.
Conclusions: Our study suggests that illness- and medication-perceptions, malleable constructs, are key aspects associated with HRQoL in PwMS, in addition to the already-known impacts of depression and anxiety. Recognizing the contribution of perceptions can have practical implications on application of personalized and tailored psychological interventions that may contribute to a better HRQoL of PwMS.
Disclosure:
Sharonne Ratzabi: nothing to disclose
Efrat Neter: nothing to disclose
Izabella Lejbkowicz: nothing to disclose
Lea Glass-Marmor: nothing to disclose
Idit Lavi: nothing to disclose
Ariel Miller: nothing to disclose
Abstract: P770
Type: Poster
Abstract Category: Therapy - symptomatic - Quality of life
Background: Health-Related Quality of Life (HRQoL) is an important patient reported outcome (PRO) in MS disease management. Physical disability and emotional factors were identified as affecting HRQoL of persons with MS (PwMS), while the effects of perceptions were considered only scarcely.
Aims: To assess the effects of physical disability, illness and medication perceptions and emotional factors on the HRQoL of PwMS.
Methods: Pilot study of 66 Relapsing Remitting PwMS treated at our MS Center. Questionnaires assessing HRQoL, demographic data, illness and medicine perceptions, and emotional factors were filled by the participants. Physical disability (EDSS) was evaluated by the treating neurologist. Univariable analysis and Hierarchical Forced Step Regression were performed to assess association of the variables with HRQoL.
Results: Univariable analysis indicated that socio-economic status (SES), EDSS, illness perception, medication perception and emotional factors were significant associated with HRQoL. Hierarchical Forced Step Regression was performed in five steps. The analysis revealed a weak association of SES (β=0.36, p< 0.01, R²model=9.9%) in the demographic step and no significant effect of EDSS in the physical disability step (R²model=12.4%). A strong significant association of illness and medicine perceptions (β=0.36, p< 0.01and β =0.23, p=0.05, respectively, and R²model=29.2%) were found in the perceptions step, in addition to the strong association of the emotional factors anxiety (β =-0.41,
p< 0.01and R² model = 37.1%) and depression (β =-0.486, p=0.02 and R² model =43.0%) shown in the fourth and fifth steps. The addition of emotional factors to the final steps of the model masked the effect of factors significant in the previous steps.
Conclusions: Our study suggests that illness- and medication-perceptions, malleable constructs, are key aspects associated with HRQoL in PwMS, in addition to the already-known impacts of depression and anxiety. Recognizing the contribution of perceptions can have practical implications on application of personalized and tailored psychological interventions that may contribute to a better HRQoL of PwMS.
Disclosure:
Sharonne Ratzabi: nothing to disclose
Efrat Neter: nothing to disclose
Izabella Lejbkowicz: nothing to disclose
Lea Glass-Marmor: nothing to disclose
Idit Lavi: nothing to disclose
Ariel Miller: nothing to disclose