Contributions
Abstract: P585
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment is common in MS, it is present throughout different disease courses and it is associated with brain atrophy. Corpus Callosum Index (CCI) is a simple and easy to perform measure of brain atrophy that correlates with selective cognitive impairment.
Goals: To describe differences in cognitive performance between Relapsing Remitting (RR) and Progressive (Pr) MS patients and its relationship with CCI.
Methods: A prospective cohort of MS patients was evaluated using a neurocognitive battery including episodic (visual/verbal) and working memory, processing speed, and cognitive-shifts tests.Total and regional (anterior, middle, posterior) CCI was obtained by a trained neurologist from sagittal T1 MRI and correlated with cognitive scores within 3 months of scanning. Cognitive Impairment diagnosis was considered when the Z scores of at least two tests were < -1.5. Disability (Expanded Disability Status Scale-EDSS), fatigue, depression and Quality of Life (QOL) scores were also obtained.
Results: One-hundred and six (106) patients were recruited, 67 RR and 39 PrMs. As expected, patients with PrMS were significantly older (mean age 56.2 vs 34.1 years), had longer disease duration (mean 15.5 vs 5 years), higher disability scores (median EDSS 6 vs 1.5), and reported higher scores in depression, fatigue and QOL. No differences were found in gender distribution. RRMS had 25.9% of patients with Cognitive Impairment vs 86.8% in the PrMS group. Compared to RRMS, PrMS scored significantly lower in every test except for cognitive-shifts, and a significant reduction of anterior and middle CCI was observed, while no differences were found in total or posterior CCI. EDSS was correlated with CCI only in the RRMS group (rp=-0.495, p< 0.001). After adjusting for covariables (age, disease duration, EDSS, fatigue, depression and QOL), Verbal Memory was correlated with anterior CCI in RRMS; Visual Memory was correlated with total and posterior CCI in PrMS; Working Memory was correlated with anterior CCI in both groups and total CCI in PrMS; Processing Speed was correlated with total and regional CCI in both groups; and cognitive shifts was only correlated with posterior CCI in PrMS.
Conclusions: Cognitive impairment is present in RR and PrMS patients with a more severe and widespread involvement in the latter group. Corpus Callosum Index correlates with selective cognitive performance and it is correlated with physical disability only in RRMS.
Disclosure:
Ethel Ciampi declare no conflict of interest
Macarena Vasquez declare no conflict of interest
Reinaldo Uribe declare no conflict of interest
Tomás Labbe declare no conflict of interest
Juan Pablo Cruz declare no conflict of interest
Arturo Marquez declare no conflict of interest
Diego Reyes declare no conflict of interest
Carmen Pinto declare no conflict of interest
Ana Reyes declare no conflict of interest
Elizabeth Vergara declare no conflict of interest
Daniella Weaver declare no conflict of interest
Patricia Feliu declare no conflict of interest
Claudia Carcamo declare no conflict of interest
Abstract: P585
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment is common in MS, it is present throughout different disease courses and it is associated with brain atrophy. Corpus Callosum Index (CCI) is a simple and easy to perform measure of brain atrophy that correlates with selective cognitive impairment.
Goals: To describe differences in cognitive performance between Relapsing Remitting (RR) and Progressive (Pr) MS patients and its relationship with CCI.
Methods: A prospective cohort of MS patients was evaluated using a neurocognitive battery including episodic (visual/verbal) and working memory, processing speed, and cognitive-shifts tests.Total and regional (anterior, middle, posterior) CCI was obtained by a trained neurologist from sagittal T1 MRI and correlated with cognitive scores within 3 months of scanning. Cognitive Impairment diagnosis was considered when the Z scores of at least two tests were < -1.5. Disability (Expanded Disability Status Scale-EDSS), fatigue, depression and Quality of Life (QOL) scores were also obtained.
Results: One-hundred and six (106) patients were recruited, 67 RR and 39 PrMs. As expected, patients with PrMS were significantly older (mean age 56.2 vs 34.1 years), had longer disease duration (mean 15.5 vs 5 years), higher disability scores (median EDSS 6 vs 1.5), and reported higher scores in depression, fatigue and QOL. No differences were found in gender distribution. RRMS had 25.9% of patients with Cognitive Impairment vs 86.8% in the PrMS group. Compared to RRMS, PrMS scored significantly lower in every test except for cognitive-shifts, and a significant reduction of anterior and middle CCI was observed, while no differences were found in total or posterior CCI. EDSS was correlated with CCI only in the RRMS group (rp=-0.495, p< 0.001). After adjusting for covariables (age, disease duration, EDSS, fatigue, depression and QOL), Verbal Memory was correlated with anterior CCI in RRMS; Visual Memory was correlated with total and posterior CCI in PrMS; Working Memory was correlated with anterior CCI in both groups and total CCI in PrMS; Processing Speed was correlated with total and regional CCI in both groups; and cognitive shifts was only correlated with posterior CCI in PrMS.
Conclusions: Cognitive impairment is present in RR and PrMS patients with a more severe and widespread involvement in the latter group. Corpus Callosum Index correlates with selective cognitive performance and it is correlated with physical disability only in RRMS.
Disclosure:
Ethel Ciampi declare no conflict of interest
Macarena Vasquez declare no conflict of interest
Reinaldo Uribe declare no conflict of interest
Tomás Labbe declare no conflict of interest
Juan Pablo Cruz declare no conflict of interest
Arturo Marquez declare no conflict of interest
Diego Reyes declare no conflict of interest
Carmen Pinto declare no conflict of interest
Ana Reyes declare no conflict of interest
Elizabeth Vergara declare no conflict of interest
Daniella Weaver declare no conflict of interest
Patricia Feliu declare no conflict of interest
Claudia Carcamo declare no conflict of interest