Contributions
Abstract: P583
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: The frequency of cognitive impairment (CI) in multiple sclerosis (MS) is variable according to the studies published in the literature. One of the most consistent findings is the slowing of processing speed, which has been proposed as a screening parameter. The aim of this study was to analyse the prevalence of cognitive impairment in a large series of patients with MS studied through a comprehensive battery of cognitive assessment.
Methods: Prospective study of 228 patients diagnosed with MS (RR, SP and PP variants) (70.6 % women, mean age 47.60±10.01 years old, schooling 15.04 ± 3.80 years). The following neuropsychological tests were administered: Digit span, Corsi"s blocks, Trail making test, Symbol digit modalities test (SDMT), Stroop color-word interference test, Rey-Osterrieth complex figure, Free and cued selective reminding test, Verbal fluency, PASAT, Boston naming test, Tower of London and Judgement line orientation. Age- and education-adjusted scaled scores (average 10, standard deviation 3) with normative data from the Spanish project of co-normalization NEURONORMA were used.
Results: At least one cognitive test was impaired in the 72.8% of the sample. In 21.1% of the patients there was impairment in one test, in 11.8% of the patients in 2 tests and in 39.9% of the sample 3 or more tests were impaired. The most affected cognitive domains were attention (19.7%) and processing speed (19.2%) followed by memory (10.1%). The SDMT obtained an area under the curve of 0.779 (cut-off point scaled score 11/12) to detect alteration in at least one cognitive domain, and 0.857 to detect impairment in at least two domains (cut-off point scale score 10/11).
Conclusions: CI is very common in MS. A normal-high performance on the SDMT allows excluding changes in other cognitive domains. However, due to the heterogeneity of cognitive profiles, it is necessary to perform a detailed neuropsychological assessment.
Disclosure:
Ana Cortés-Martínez: nothing to disclose
Rocío Nur Villar-Quiles: nothing to disclose
Jordi A. Matías-Guiu: nothing to disclose
Celia Oreja-Guevara: nothing to disclose
Jorge Matías-Guiu: nothing to disclose
Abstract: P583
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: The frequency of cognitive impairment (CI) in multiple sclerosis (MS) is variable according to the studies published in the literature. One of the most consistent findings is the slowing of processing speed, which has been proposed as a screening parameter. The aim of this study was to analyse the prevalence of cognitive impairment in a large series of patients with MS studied through a comprehensive battery of cognitive assessment.
Methods: Prospective study of 228 patients diagnosed with MS (RR, SP and PP variants) (70.6 % women, mean age 47.60±10.01 years old, schooling 15.04 ± 3.80 years). The following neuropsychological tests were administered: Digit span, Corsi"s blocks, Trail making test, Symbol digit modalities test (SDMT), Stroop color-word interference test, Rey-Osterrieth complex figure, Free and cued selective reminding test, Verbal fluency, PASAT, Boston naming test, Tower of London and Judgement line orientation. Age- and education-adjusted scaled scores (average 10, standard deviation 3) with normative data from the Spanish project of co-normalization NEURONORMA were used.
Results: At least one cognitive test was impaired in the 72.8% of the sample. In 21.1% of the patients there was impairment in one test, in 11.8% of the patients in 2 tests and in 39.9% of the sample 3 or more tests were impaired. The most affected cognitive domains were attention (19.7%) and processing speed (19.2%) followed by memory (10.1%). The SDMT obtained an area under the curve of 0.779 (cut-off point scaled score 11/12) to detect alteration in at least one cognitive domain, and 0.857 to detect impairment in at least two domains (cut-off point scale score 10/11).
Conclusions: CI is very common in MS. A normal-high performance on the SDMT allows excluding changes in other cognitive domains. However, due to the heterogeneity of cognitive profiles, it is necessary to perform a detailed neuropsychological assessment.
Disclosure:
Ana Cortés-Martínez: nothing to disclose
Rocío Nur Villar-Quiles: nothing to disclose
Jordi A. Matías-Guiu: nothing to disclose
Celia Oreja-Guevara: nothing to disclose
Jorge Matías-Guiu: nothing to disclose