Contributions
Abstract: P580
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment (CI) can present in multiple sclerosis (MS) patients at any time, regardless of the disease severity and activity. It seems that cognitive decline during MS relapses also can occur. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was recommended as brief, simple, and specific instrument for the evaluation of cognition in MS patients. However, it is unknown whether it is possible to detect the cognitive changes during MS relapse with BICAMS.
Objectives: The purpose of the study was to assess the cognitive status with the Lithuanian version of BICAMS during MS relapse and 3-month follow-up period.
Material and methods: 90 MS patients and 30 cognitively normal control subjects, matched on age, gender and level of education were enrolled. 60 MS patients were assessed during MS relapse, 1st and 3rd mth after relapse and 30 MS patients - during remission. Cognitive functions were assessed with the BICAMS tests.
Results: MS patients performed significantly worse than controls on the three neuropsychological tests of BICAMS (p< 0.001). Relapsing MS patients performed SDMT test worse than remitting MS patients (p< 0.001). Significant increment of SDMT, BVMT-R and CVLT-II test scores was observed during the 1st mth after relapse in relapsing patients (p< 0.001) and of CVLT-II test - during the 3rd mth. The improvement of SDMT score after relapse was influenced by the EDSS score changes, age and education, the improvement of BVMT-R score - by the IFN-beta biological activity and duration of immunomodulatory therapy and the improvement of CVLT-II - by the duration of relapse (p< 0.001). Comparison of men"s and women"s memory changes after relapse revealed visual memory improvement in men and verbal learning in women (p< 0.05).
Conclusions: Clinically meaningful impairment in cognitive status changes was observed in relapsing MS patients. The increment of SDMT, BVMT-R and CVLT-II scores after MS relapse was influenced by different factors.
Disclosure: Nothing to disclose
Abstract: P580
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment (CI) can present in multiple sclerosis (MS) patients at any time, regardless of the disease severity and activity. It seems that cognitive decline during MS relapses also can occur. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was recommended as brief, simple, and specific instrument for the evaluation of cognition in MS patients. However, it is unknown whether it is possible to detect the cognitive changes during MS relapse with BICAMS.
Objectives: The purpose of the study was to assess the cognitive status with the Lithuanian version of BICAMS during MS relapse and 3-month follow-up period.
Material and methods: 90 MS patients and 30 cognitively normal control subjects, matched on age, gender and level of education were enrolled. 60 MS patients were assessed during MS relapse, 1st and 3rd mth after relapse and 30 MS patients - during remission. Cognitive functions were assessed with the BICAMS tests.
Results: MS patients performed significantly worse than controls on the three neuropsychological tests of BICAMS (p< 0.001). Relapsing MS patients performed SDMT test worse than remitting MS patients (p< 0.001). Significant increment of SDMT, BVMT-R and CVLT-II test scores was observed during the 1st mth after relapse in relapsing patients (p< 0.001) and of CVLT-II test - during the 3rd mth. The improvement of SDMT score after relapse was influenced by the EDSS score changes, age and education, the improvement of BVMT-R score - by the IFN-beta biological activity and duration of immunomodulatory therapy and the improvement of CVLT-II - by the duration of relapse (p< 0.001). Comparison of men"s and women"s memory changes after relapse revealed visual memory improvement in men and verbal learning in women (p< 0.05).
Conclusions: Clinically meaningful impairment in cognitive status changes was observed in relapsing MS patients. The increment of SDMT, BVMT-R and CVLT-II scores after MS relapse was influenced by different factors.
Disclosure: Nothing to disclose