Contributions
Abstract: P573
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment is associated with cortical and subcortical atrophy and demyelinating lesions in patients with multiple sclerosis (MS). A profile of cognitive impairment and its structural correlates in patients with clinically isolated syndrome (CIS) are poorly understood. The aim was to characterize a profile of cognitive impairment in patients with CIS and its association with structural brain changes.
Methods: Patients with CIS (n=51) and age-, gender- and education-matched healthy control participants (n=44) underwent testing with an extensive neuropsychological battery covering major cognitive domains and MRI brain scan with automated volumetric measurement of normalized brain parenchymal (nBP) volume, normalized white and grey matter (nWM and nGM) volume, regional cortical and subcortical grey matter volume and white matter lesion volume.
Results: The CIS group had worse performance in verbal and nonverbal memory, information processing speed/attention/working memory, executive and visuo-spatial functions (p≤.040), but not in language functions (p=.398) compared to controls. Cognitive impairment was present in 18 to 37% of participants in the CIS group. The CIS group had reduced nBP (p=.006), nWM (p=.029) and nGM (p=.027) volume and regional cortical and subcortical grey matter volume, predominantly in fronto-temporal regions and thalamus (p≤.019) compared to controls. Worse performance in visuo-spatial functions was associated with lower nWM volume (r=0.31; p=.037). The higher EDSS score was related to lower nBP volume (r=-0.38, p=.011).
Conclusion: Cognitive impairment was present in up to one third of patients with CIS and affected almost all cognitive domains with relative sparing of language functions. Brain atrophy was mostly pronounced in cortical grey matter of fronto-temporal regions and thalamus in patients with CIS. Lower nWM volume was associated with worse performance in visuo-spatial functions, while lower nBP volume was associated with greater clinical disability among patients with CIS.
Disclosure:
Disclosure: The authors report no conflict of interest.
Grant support: Grant Agency of the Charles University in Prague Grants No. 546113 (Dr. Hynčicová);
Internal Grant Agency of the Ministry of Health of the Czech Republic Grant NT/12385-5 (Dr. Meluzínová);
European Regional Development Fund - Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123) and by project ICRC-ERA-HumanBridge (no.316345) (Drs. Laczó, Vyhnálek, Nikolai, Hort);
Ministry of Health, Czech Republic - conceptual development of research organization, University Hospital Motol, Prague, Czech Republic 00064203 (Drs. Laczó, Hynčicová, Martinkovič, Kalina, Vyhnálek, Nikolai, Hort, Meluzínová).
Abstract: P573
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment is associated with cortical and subcortical atrophy and demyelinating lesions in patients with multiple sclerosis (MS). A profile of cognitive impairment and its structural correlates in patients with clinically isolated syndrome (CIS) are poorly understood. The aim was to characterize a profile of cognitive impairment in patients with CIS and its association with structural brain changes.
Methods: Patients with CIS (n=51) and age-, gender- and education-matched healthy control participants (n=44) underwent testing with an extensive neuropsychological battery covering major cognitive domains and MRI brain scan with automated volumetric measurement of normalized brain parenchymal (nBP) volume, normalized white and grey matter (nWM and nGM) volume, regional cortical and subcortical grey matter volume and white matter lesion volume.
Results: The CIS group had worse performance in verbal and nonverbal memory, information processing speed/attention/working memory, executive and visuo-spatial functions (p≤.040), but not in language functions (p=.398) compared to controls. Cognitive impairment was present in 18 to 37% of participants in the CIS group. The CIS group had reduced nBP (p=.006), nWM (p=.029) and nGM (p=.027) volume and regional cortical and subcortical grey matter volume, predominantly in fronto-temporal regions and thalamus (p≤.019) compared to controls. Worse performance in visuo-spatial functions was associated with lower nWM volume (r=0.31; p=.037). The higher EDSS score was related to lower nBP volume (r=-0.38, p=.011).
Conclusion: Cognitive impairment was present in up to one third of patients with CIS and affected almost all cognitive domains with relative sparing of language functions. Brain atrophy was mostly pronounced in cortical grey matter of fronto-temporal regions and thalamus in patients with CIS. Lower nWM volume was associated with worse performance in visuo-spatial functions, while lower nBP volume was associated with greater clinical disability among patients with CIS.
Disclosure:
Disclosure: The authors report no conflict of interest.
Grant support: Grant Agency of the Charles University in Prague Grants No. 546113 (Dr. Hynčicová);
Internal Grant Agency of the Ministry of Health of the Czech Republic Grant NT/12385-5 (Dr. Meluzínová);
European Regional Development Fund - Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123) and by project ICRC-ERA-HumanBridge (no.316345) (Drs. Laczó, Vyhnálek, Nikolai, Hort);
Ministry of Health, Czech Republic - conceptual development of research organization, University Hospital Motol, Prague, Czech Republic 00064203 (Drs. Laczó, Hynčicová, Martinkovič, Kalina, Vyhnálek, Nikolai, Hort, Meluzínová).