Contributions
Abstract: P567
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: Cervical vestibular evoked myogenic potentials (cVEMPs) are inhibitory electrical potentials generated after a sound stimulus, originated in the saccule and conducted by the lower portion of the vestibular nerve all the way to the central nervous system (CNS), generating inhibitory electrical responses picked up by electrodes placed on the sternocleidomastoid muscle. A normal middle ear, inferior vestibular nerve and nucleus, vestibulospinal tract, the spinal accessory nucleus and nerve are needed for response generation. The aim of the study was to evaluate the contribution of cVEMPs in detecting brainstem involvement in multiple sclerosis (MS) and to compare the results with auditory evoked potentials (AEPs) and MRI.
Material and methods: 30 MS patients (18 women and 12 men with a mean age of 30years (range 18-45years) and 30 healthy controls (18 women and 12 men with a mean age of 30 years (range 19-48 years) were included in the study. The latencies of peaks p13 and n23, peak-to-peak amplitude of p13-n23 divided by a mean prestimulus EMG (amplitude ratio) recorded during cVEMP testing were measured. For the AEPs I-III and III-V interpeak latencies were taken into consideration. Latencies exceeding 2.5 standard deviations were accepted as abnormal.
Results: Brainstem involvement on MRI was present in 13 patients (44%). For cVEMPs there were 9 patients (30%) with prolonged latencies. AEP abnormalities were detected in 4 patients (13%). None of the electrophysiological tests used showed statistically significant advantage in detecting brainstem lesions.
Conclusion: Though cVEMPs are superior to AEPs in detecting brainstem involvement, MRI is the most sensitive method.
Disclosure:
Gökçe Kavasoğlu: Nothing to disclose
Nur Yüceyar: Nothing to disclose
Neşe Çelebisoy: Nothing to disclose
Abstract: P567
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: Cervical vestibular evoked myogenic potentials (cVEMPs) are inhibitory electrical potentials generated after a sound stimulus, originated in the saccule and conducted by the lower portion of the vestibular nerve all the way to the central nervous system (CNS), generating inhibitory electrical responses picked up by electrodes placed on the sternocleidomastoid muscle. A normal middle ear, inferior vestibular nerve and nucleus, vestibulospinal tract, the spinal accessory nucleus and nerve are needed for response generation. The aim of the study was to evaluate the contribution of cVEMPs in detecting brainstem involvement in multiple sclerosis (MS) and to compare the results with auditory evoked potentials (AEPs) and MRI.
Material and methods: 30 MS patients (18 women and 12 men with a mean age of 30years (range 18-45years) and 30 healthy controls (18 women and 12 men with a mean age of 30 years (range 19-48 years) were included in the study. The latencies of peaks p13 and n23, peak-to-peak amplitude of p13-n23 divided by a mean prestimulus EMG (amplitude ratio) recorded during cVEMP testing were measured. For the AEPs I-III and III-V interpeak latencies were taken into consideration. Latencies exceeding 2.5 standard deviations were accepted as abnormal.
Results: Brainstem involvement on MRI was present in 13 patients (44%). For cVEMPs there were 9 patients (30%) with prolonged latencies. AEP abnormalities were detected in 4 patients (13%). None of the electrophysiological tests used showed statistically significant advantage in detecting brainstem lesions.
Conclusion: Though cVEMPs are superior to AEPs in detecting brainstem involvement, MRI is the most sensitive method.
Disclosure:
Gökçe Kavasoğlu: Nothing to disclose
Nur Yüceyar: Nothing to disclose
Neşe Çelebisoy: Nothing to disclose