Contributions
Abstract: P566
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: Vestibular evoked myogenic potentials (VEMP) have been recognized as a reliable method in detection of symptomatic and asymptomatic brainstem lesions in multiple sclerosis (MS). We have previously reported that VEMP score demonstrated significant correlation with Expanded Disability Status Scale (EDSS) in a cross-sectional study on MS patients. The aim of this study was to evaluate the VEMP score as a predictor of disability progression in long-term follow-up of MS patients.
Methods: Complete baseline work-up at the study entry consisting of EDSS, brainstem functional system score (BSFS), presence of brainstem lesions on the brain MRI and ocular and cervical VEMPs was performed in 100 MS patients. Second complete clinical and neuroradiological analysis was done three years after with additional data about clinical evidence of disease activity which included number of relapses and increase in EDSS, total number of new T2 lesions and new gadolinium enhancing lesions (Gd+), and was available for 81 patients. Results were correlated with the VEMP score value at the study entry.
Results: EDSS at follow-up significantly correlated with values of the VEMP score and ocular VEMP score at the study entry (R=0.223, p=0.045 and R=0.227, p=0.042, respectively). Number of relapses during follow up period correlated significantly with baseline and follow up EDSS (R=0.295, p=0.008 and R=0.448, p< 0.001, respectively), as well as with number of new T2 lesions and new Gd+ lesions (R=0.349, p=0.001 and R=0.319, p=0.004, respectively) during follow up period.
Conclusions: The VEMP score is a promising marker of future disability development in patients with relapsing-remitting MS.
Disclosure:
Tereza Gabelić: nothing to disclose
Magdalena Krbot Skoric: nothing to disclose
Ivan Adamec: nothing to disclose
Mario Habek nothing to disclose
Abstract: P566
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: Vestibular evoked myogenic potentials (VEMP) have been recognized as a reliable method in detection of symptomatic and asymptomatic brainstem lesions in multiple sclerosis (MS). We have previously reported that VEMP score demonstrated significant correlation with Expanded Disability Status Scale (EDSS) in a cross-sectional study on MS patients. The aim of this study was to evaluate the VEMP score as a predictor of disability progression in long-term follow-up of MS patients.
Methods: Complete baseline work-up at the study entry consisting of EDSS, brainstem functional system score (BSFS), presence of brainstem lesions on the brain MRI and ocular and cervical VEMPs was performed in 100 MS patients. Second complete clinical and neuroradiological analysis was done three years after with additional data about clinical evidence of disease activity which included number of relapses and increase in EDSS, total number of new T2 lesions and new gadolinium enhancing lesions (Gd+), and was available for 81 patients. Results were correlated with the VEMP score value at the study entry.
Results: EDSS at follow-up significantly correlated with values of the VEMP score and ocular VEMP score at the study entry (R=0.223, p=0.045 and R=0.227, p=0.042, respectively). Number of relapses during follow up period correlated significantly with baseline and follow up EDSS (R=0.295, p=0.008 and R=0.448, p< 0.001, respectively), as well as with number of new T2 lesions and new Gd+ lesions (R=0.349, p=0.001 and R=0.319, p=0.004, respectively) during follow up period.
Conclusions: The VEMP score is a promising marker of future disability development in patients with relapsing-remitting MS.
Disclosure:
Tereza Gabelić: nothing to disclose
Magdalena Krbot Skoric: nothing to disclose
Ivan Adamec: nothing to disclose
Mario Habek nothing to disclose