Abstract: P560
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: The aim of this study was to explore correlation between upper extremity function measured with 9-Hole Peg Test (9HPT), brainstem and cervical spinal cord MRI lesions and somatosensory evoked potentials of the median nerve (mSSEP).
Methods: One hundred and nine patients with clinically isolated syndrome (CIS) were included in this study (78 females), mean age of 32.4±8.7. All patients were right handed. Brain MRI, mSSEP and 9HPT were performed for each patient. Cervical spinal cord MRI was available for 82 patients. Results of 9HPT for dominant and non-dominant hand, presence of T2 lesions in the brainstem and cervical spinal cord and N13-N20 interlatency of the mSSEP for each hand were analyzed.
Results: For the non-dominant hand there was statistically significant correlation between N13-N20 interlatency of the mSSEP and results of the 9HPT (r=0.216, p=0.025). For the dominant hand there was no statistically significant correlation between N13-N20 interlatency of the mSSEP and the 9HPT. Brainstem lesions were present in 46 patients (42.2%). When compared to patients without brainstem lesions, those with brainstem lesions had significantly prolonged average time to perform 9HPT for both dominant and nondominant hand (median 20.58 vs. 19.20 s, p=0.023 and 21.88 vs. 19.90 s, p=0.003, respectively). Furthermore, patients with brainstem lesions had significantly prolonged interlatency of the mSSEP for the nondominant hand (6.8 vs 6.2 ms, p=0.018). No changes were observed with regard to cervical spinal cord lesions.
Conclusion: Both morphological (MRI) and functional (mSSEP) measures of MS disease burden influence upper extremity function. This influence seems to be restricted to the brainstem lesions.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622
Abstract: P560
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: The aim of this study was to explore correlation between upper extremity function measured with 9-Hole Peg Test (9HPT), brainstem and cervical spinal cord MRI lesions and somatosensory evoked potentials of the median nerve (mSSEP).
Methods: One hundred and nine patients with clinically isolated syndrome (CIS) were included in this study (78 females), mean age of 32.4±8.7. All patients were right handed. Brain MRI, mSSEP and 9HPT were performed for each patient. Cervical spinal cord MRI was available for 82 patients. Results of 9HPT for dominant and non-dominant hand, presence of T2 lesions in the brainstem and cervical spinal cord and N13-N20 interlatency of the mSSEP for each hand were analyzed.
Results: For the non-dominant hand there was statistically significant correlation between N13-N20 interlatency of the mSSEP and results of the 9HPT (r=0.216, p=0.025). For the dominant hand there was no statistically significant correlation between N13-N20 interlatency of the mSSEP and the 9HPT. Brainstem lesions were present in 46 patients (42.2%). When compared to patients without brainstem lesions, those with brainstem lesions had significantly prolonged average time to perform 9HPT for both dominant and nondominant hand (median 20.58 vs. 19.20 s, p=0.023 and 21.88 vs. 19.90 s, p=0.003, respectively). Furthermore, patients with brainstem lesions had significantly prolonged interlatency of the mSSEP for the nondominant hand (6.8 vs 6.2 ms, p=0.018). No changes were observed with regard to cervical spinal cord lesions.
Conclusion: Both morphological (MRI) and functional (mSSEP) measures of MS disease burden influence upper extremity function. This influence seems to be restricted to the brainstem lesions.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622