Contributions
Abstract: P482
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Imaging
Background: Abnormal functional connectivity patterns have been observed in multiple sclerosis (MS) patients compared to healthy subjects (HS) using resting state fMRI (rsfMRI); in particular the sensorimotor network shows increased connectivity in MS. Here we explore how these resting functional abnormalities relate to task activations and task-based connectivity.
Methods: 26 Right-handed (RH) subjects (10 HS: 5F; aged 31 (3.85) and 16 relapsing-remitting (RR) MS: 11F; aged 34 (3.23); median (range) EDSS =3.0 (1.5, 6.5)) were recruited. The 3T fMRI protocol consisted of:
1) A visuomotor event-related power-grip RH task and
2) rsfMRI.
We investigated:
- Task related functional segregation (activations);
- Task related functional integration - effective connectivity (using Psychophysiological Interaction (PPI));
- Functional integration - functional connectivity at rest (using rsfMRI);
- Correlations of the aforementioned measures with clinical scores.
Results:
- Task fMRI: Greater functional activation was seen in MS compared to HS, especially in the ipsilateral hemisphere, including sensorimotor, associative and sub-cortical areas. Positive correlations with clinical scores were observed (P< 0.001);
- Task Connectivity: PPI of M1 to the rest of the brain was preserved contralaterally in MS patients, compared to HS, but was completely lost in the ipsilateral hemisphere;
- rsfMRI: Conversely, higher rsfMRI connectivity was observed in the same regions that showed loss of task-based connectivity in MS;
- The most indicative positive correlations with clinical scores (P< 0.001) were found between increased rsfMRI functional connectivity and EDSS. On the other hand, contralateral task-based connectivity was decreased with increasing EDSS.
Disclosure:
Adnan Alahmadi, Matteo Pardini, Rebecca Samson, Peter Zeidman, Egidio D´Angelo and Karl Friston have nothing to disclose.
Carmen Tur has received an ECTRIMS post-doctoral research fellowship in 2015. She has also received honoraria and support for travelling from Bayer-Schering, Teva, Merck-Serono and Serono Foundation, Biogen, Sanofi-Aventis, Novartis, and Ismar Healthcare.
Ahmed Toosy has received speaker honoraria from Biomedia, Sereno Symposia International Foundation, Bayer and meeting expenses from Biogen Idec.
Claudia GWK is on the editorial board of Functional Neurology and receives research grants (PI and co-applicant) from ISRT, EPSRC, Wings for Life, UK MS Society, Horizon2020, Biogen and Novartis.
Abstract: P482
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Imaging
Background: Abnormal functional connectivity patterns have been observed in multiple sclerosis (MS) patients compared to healthy subjects (HS) using resting state fMRI (rsfMRI); in particular the sensorimotor network shows increased connectivity in MS. Here we explore how these resting functional abnormalities relate to task activations and task-based connectivity.
Methods: 26 Right-handed (RH) subjects (10 HS: 5F; aged 31 (3.85) and 16 relapsing-remitting (RR) MS: 11F; aged 34 (3.23); median (range) EDSS =3.0 (1.5, 6.5)) were recruited. The 3T fMRI protocol consisted of:
1) A visuomotor event-related power-grip RH task and
2) rsfMRI.
We investigated:
- Task related functional segregation (activations);
- Task related functional integration - effective connectivity (using Psychophysiological Interaction (PPI));
- Functional integration - functional connectivity at rest (using rsfMRI);
- Correlations of the aforementioned measures with clinical scores.
Results:
- Task fMRI: Greater functional activation was seen in MS compared to HS, especially in the ipsilateral hemisphere, including sensorimotor, associative and sub-cortical areas. Positive correlations with clinical scores were observed (P< 0.001);
- Task Connectivity: PPI of M1 to the rest of the brain was preserved contralaterally in MS patients, compared to HS, but was completely lost in the ipsilateral hemisphere;
- rsfMRI: Conversely, higher rsfMRI connectivity was observed in the same regions that showed loss of task-based connectivity in MS;
- The most indicative positive correlations with clinical scores (P< 0.001) were found between increased rsfMRI functional connectivity and EDSS. On the other hand, contralateral task-based connectivity was decreased with increasing EDSS.
Disclosure:
Adnan Alahmadi, Matteo Pardini, Rebecca Samson, Peter Zeidman, Egidio D´Angelo and Karl Friston have nothing to disclose.
Carmen Tur has received an ECTRIMS post-doctoral research fellowship in 2015. She has also received honoraria and support for travelling from Bayer-Schering, Teva, Merck-Serono and Serono Foundation, Biogen, Sanofi-Aventis, Novartis, and Ismar Healthcare.
Ahmed Toosy has received speaker honoraria from Biomedia, Sereno Symposia International Foundation, Bayer and meeting expenses from Biogen Idec.
Claudia GWK is on the editorial board of Functional Neurology and receives research grants (PI and co-applicant) from ISRT, EPSRC, Wings for Life, UK MS Society, Horizon2020, Biogen and Novartis.