Contributions
Abstract: P419
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Genetics /Epigenetics and Pharmacogenetics
Background: Individuals with a family member affected by multiple sclerosis (MS) are at higher risk of developing the disease. The familial risk of MS in relation to the age at the disease onset has not been investigated and may disentangle the interplay of gene and environment in development of MS.
Goals: To estimate and compare the relative risks (RRs) of childhood- (onset age ≤16 years) and late-onset MS (onset age ≥50 years) for individuals with a relative diagnosed with MS.
Methods: We used three nationwide registers in Sweden; the National Patient Register (NPR) to identify MS cases and controls, the Multigenerational register for familial relations and the Swedish MS register to obtain MS onset age. RRs of childhood-, adolescent- (onset age between 10-16 years) and late-onset MS in individuals with a relative diagnosed with MS were calculated in a matched case-control design.
Results: We identified 457 childhood-onset and 1,149 late-onset MS patients and included 2,981,645 randomly selected matched controls. The RRs of developing childhood-onset MS in individuals with a first and second degree relative diagnosed with MS were 7.02 (95% Confidence Intervals (CI): 4.47 to 11.04) and 2.64 (95%CI: 1.54 to 4.51), respectively. The RRs of late-onset MS in individuals with a first and second degree relative diagnosed with MS were 6.81(95%CI: 5.28 to 8.78) and 2.30 (95%CI: 1.49 to 3.54). The RRs of adolescent-onset MS (n=371) in individuals with a first and second degree relative diagnosed with MS were 7.95 (95%CI: 4.71 to 13.42) and 2.71 (95%CI: 1.50 to 4.90), respectively.
Conclusions: Familial recurrence risk of MS, which to large extent represents genetic susceptibility to the disease, was significantly increased and was remarkably comparable in patients at the two ends of MS onset age distribution. These findings may indicate that age at development of MS is more influenced by environmental factor(s) than genetics.
Disclosure:
Funding: The Swedish Research Council, the Swedish Research Council for Health, Working Life and Welfare
JS, HW, CA and AM: nothing to disclose.
JH has received honoraria for serving on advisory boards for Biogen and Novartis and speaker"s fees from Biogen, Merck-Serono, Bayer-Schering, Teva and Sanofi-Aventis. He has served as P.I. for projects, or received unrestricted research support from, Biogen, Merck-Serono, Sanofi-Genzyme and Novartis.
Abstract: P419
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Genetics /Epigenetics and Pharmacogenetics
Background: Individuals with a family member affected by multiple sclerosis (MS) are at higher risk of developing the disease. The familial risk of MS in relation to the age at the disease onset has not been investigated and may disentangle the interplay of gene and environment in development of MS.
Goals: To estimate and compare the relative risks (RRs) of childhood- (onset age ≤16 years) and late-onset MS (onset age ≥50 years) for individuals with a relative diagnosed with MS.
Methods: We used three nationwide registers in Sweden; the National Patient Register (NPR) to identify MS cases and controls, the Multigenerational register for familial relations and the Swedish MS register to obtain MS onset age. RRs of childhood-, adolescent- (onset age between 10-16 years) and late-onset MS in individuals with a relative diagnosed with MS were calculated in a matched case-control design.
Results: We identified 457 childhood-onset and 1,149 late-onset MS patients and included 2,981,645 randomly selected matched controls. The RRs of developing childhood-onset MS in individuals with a first and second degree relative diagnosed with MS were 7.02 (95% Confidence Intervals (CI): 4.47 to 11.04) and 2.64 (95%CI: 1.54 to 4.51), respectively. The RRs of late-onset MS in individuals with a first and second degree relative diagnosed with MS were 6.81(95%CI: 5.28 to 8.78) and 2.30 (95%CI: 1.49 to 3.54). The RRs of adolescent-onset MS (n=371) in individuals with a first and second degree relative diagnosed with MS were 7.95 (95%CI: 4.71 to 13.42) and 2.71 (95%CI: 1.50 to 4.90), respectively.
Conclusions: Familial recurrence risk of MS, which to large extent represents genetic susceptibility to the disease, was significantly increased and was remarkably comparable in patients at the two ends of MS onset age distribution. These findings may indicate that age at development of MS is more influenced by environmental factor(s) than genetics.
Disclosure:
Funding: The Swedish Research Council, the Swedish Research Council for Health, Working Life and Welfare
JS, HW, CA and AM: nothing to disclose.
JH has received honoraria for serving on advisory boards for Biogen and Novartis and speaker"s fees from Biogen, Merck-Serono, Bayer-Schering, Teva and Sanofi-Aventis. He has served as P.I. for projects, or received unrestricted research support from, Biogen, Merck-Serono, Sanofi-Genzyme and Novartis.