Contributions
Abstract: P384
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Pathology
Introduction: Vascular disease burden may contribute to Multiple Sclerosis (MS) progression and reduced life expectancy. Few in vivo studies assessed markers of atherosclerosis with no post mortem study to date having systematically evaluated vascular burden in MS. We aim to obtain a reliable systemic vascular disease score determined by autopsy and to compare it in MS versus non-MS cases.
Materials and methods: MS and non-MS cases older than 35 were selected from the Oxford Brain Bank (1971-2001). The following variables were obtained by two independent raters from autopsy reports: gender, age at death, cause of death, aorta and coronary arteries atheroma; cardiac weight; renal hypertensive disease (RH); myocardial infarction (MI); and stroke. A total systemic vascular disease score (SVDs) was computed from individual variables.
Results: 71 MS cases (mean age 60.9±12.2, 57.7% females and 40 controls (mean age 62.1±13.3, 55.5 % females) were included, with no significant differences in age or gender between groups. In terms of causes of death, infections were more common in MS compared to controls, while cancer and stroke/MI were more common in controls. No significant differences between individual scores of arterial atheroma, RD, MI or stroke were found between groups. Heart weight and ischemic stroke were greater in controls compared to MS, but this difference was no longer significant after excluding cases with stroke/MI deaths from both groups. However even excluding these cases total SVDs was lower in MS cases when compared with controls.
Conclusion: In our cohort, we found lower total SVDs in MS cases when compared with controls. This is the first study to combine detailed systemic autopsy findings related to vascular disease in MS cases and sets the stage for systematic interrogation of the interaction of vascular disease and MS pathology.
Disclosure: Nothing to disclose
Abstract: P384
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Pathology
Introduction: Vascular disease burden may contribute to Multiple Sclerosis (MS) progression and reduced life expectancy. Few in vivo studies assessed markers of atherosclerosis with no post mortem study to date having systematically evaluated vascular burden in MS. We aim to obtain a reliable systemic vascular disease score determined by autopsy and to compare it in MS versus non-MS cases.
Materials and methods: MS and non-MS cases older than 35 were selected from the Oxford Brain Bank (1971-2001). The following variables were obtained by two independent raters from autopsy reports: gender, age at death, cause of death, aorta and coronary arteries atheroma; cardiac weight; renal hypertensive disease (RH); myocardial infarction (MI); and stroke. A total systemic vascular disease score (SVDs) was computed from individual variables.
Results: 71 MS cases (mean age 60.9±12.2, 57.7% females and 40 controls (mean age 62.1±13.3, 55.5 % females) were included, with no significant differences in age or gender between groups. In terms of causes of death, infections were more common in MS compared to controls, while cancer and stroke/MI were more common in controls. No significant differences between individual scores of arterial atheroma, RD, MI or stroke were found between groups. Heart weight and ischemic stroke were greater in controls compared to MS, but this difference was no longer significant after excluding cases with stroke/MI deaths from both groups. However even excluding these cases total SVDs was lower in MS cases when compared with controls.
Conclusion: In our cohort, we found lower total SVDs in MS cases when compared with controls. This is the first study to combine detailed systemic autopsy findings related to vascular disease in MS cases and sets the stage for systematic interrogation of the interaction of vascular disease and MS pathology.
Disclosure: Nothing to disclose