Contributions
Abstract: P380
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Objective: In this study we aimed to analyze the relationship of the visual function tests with the disability scales and to investigate their value in detecting overt or subclinical optical neuritis (ON) in MS.
Material and method: 66 MS patients were included. Of these, 59(89,4%) had relapsing-remitting, and 7(10,6%) secondary progressive. Patients were divided into two groups as those who have ON and who have not. EDSS, MSFC scores were calculated. The examinations carried out were as follows: visual field test, visual acuity(VA) with high contrast(100%) and low-contrast(2,5% and 1,25%) cards, Snellen scale, visual evoked potential(VEP) and optic coherence tomography(OCT). The National Eye Institute 25-item Visual Function Questionnaire(NEI-VFQ-25) which measures the influence of visual disability and visual symptoms on generic health domains, was applied.
Results: 132 eyes of 66 MS patients, 48 females(72,7%) and 18 males(27,3%) with ages ranging from 18 to 49(36,8±7,3), were included. Significantly more visual affection was detected in the ON group with low-contrast VA cards compared to high contrast VA cards and Snellen scale(p=0,007). Average peripapillary retinal nerve fiber layer(pRNFL), ganglion cell layer(GCL), macular RNFL(mRNFL) thickness and total macular volume were found significantly less in 65 eyes with ON history compared to those who had no such previous history(p< 0,0001; p=0,028; p=0,002; p=0,025). When homologous quadrants of visual fields and pRNFL thickness in OCT were compared; OCT revealed more and statistically different abnormalities(p< 0,001). Correlations of pRNFL with VEP latency and low-contrast VA charts were found significant(p< 0,001). Whereas a significant correlation between low-contrast VA cards and VEP abnormalities was found. Significant relationships were detected between low-contrast VA cards and NEI-VFQ-25 test, also disability scales (EDSS, MSFC)(p< 0,0001).
Conclusion: Low-contrast VA test that is superior in displaying alterations of visual activity. Combined with VEP and OCT, low-contrast VA test applied at certain intervals can detect subclinical optic abnormality with high accuracy.
Disclosure:
no financial disclosure
nothing to disclosure
Abstract: P380
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Objective: In this study we aimed to analyze the relationship of the visual function tests with the disability scales and to investigate their value in detecting overt or subclinical optical neuritis (ON) in MS.
Material and method: 66 MS patients were included. Of these, 59(89,4%) had relapsing-remitting, and 7(10,6%) secondary progressive. Patients were divided into two groups as those who have ON and who have not. EDSS, MSFC scores were calculated. The examinations carried out were as follows: visual field test, visual acuity(VA) with high contrast(100%) and low-contrast(2,5% and 1,25%) cards, Snellen scale, visual evoked potential(VEP) and optic coherence tomography(OCT). The National Eye Institute 25-item Visual Function Questionnaire(NEI-VFQ-25) which measures the influence of visual disability and visual symptoms on generic health domains, was applied.
Results: 132 eyes of 66 MS patients, 48 females(72,7%) and 18 males(27,3%) with ages ranging from 18 to 49(36,8±7,3), were included. Significantly more visual affection was detected in the ON group with low-contrast VA cards compared to high contrast VA cards and Snellen scale(p=0,007). Average peripapillary retinal nerve fiber layer(pRNFL), ganglion cell layer(GCL), macular RNFL(mRNFL) thickness and total macular volume were found significantly less in 65 eyes with ON history compared to those who had no such previous history(p< 0,0001; p=0,028; p=0,002; p=0,025). When homologous quadrants of visual fields and pRNFL thickness in OCT were compared; OCT revealed more and statistically different abnormalities(p< 0,001). Correlations of pRNFL with VEP latency and low-contrast VA charts were found significant(p< 0,001). Whereas a significant correlation between low-contrast VA cards and VEP abnormalities was found. Significant relationships were detected between low-contrast VA cards and NEI-VFQ-25 test, also disability scales (EDSS, MSFC)(p< 0,0001).
Conclusion: Low-contrast VA test that is superior in displaying alterations of visual activity. Combined with VEP and OCT, low-contrast VA test applied at certain intervals can detect subclinical optic abnormality with high accuracy.
Disclosure:
no financial disclosure
nothing to disclosure