Contributions
Abstract: P377
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: The most common clinical manifestation in demyelinating disorder with serum anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody has been revealed to be optic neuritis (ON). However, its characteristics in optic MRI and visual prognosis, compared to optic neuritis in other demyelinating disorders like multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD), are not fully known.
Methods: We retrospectively collected 69 MS patients with ON history (MS-ON; 75 ON-eyes), 23 NMOSD patients with ON history (NMOSD-ON; 27 ON-eyes), and 17 anti-MOG-Ab (+) patients with ON history (MOG-ON; 24 ON-eyes), all of whom visited and were followed up in Tohoku University Hospital between 2005 and 2015. The following information was collected: sex, onset age of ON, distribution of ON-lesions, ON-lesion length, nadir of visual acuity (VA) in the acute phase, and the latest VA in the chronic phase.
Results: The onset age of ON was higher in NMOSD-ON. ON-lesion lengths in the acute phase were not significantly different among the three subtypes, though MOG-ON showed slightly longer ON-lesions. Intra-orbital lesions were the most frequent in MS-ON and NMOSD-ON, but intra-cranial lesions without chiasmal lesions were the most frequent in MOG-ON. The appearance of ON-lesions in the acute phase was the longest and most prominent in MOG-ON with severe swelling and meandering. Nadirs of VA in the acute phase were not significantly different among the three subtypes, but the latest VA in the chronic phase was significantly better in MOG-ON with almost full-recoveries. The visual prognosis in NMOSD-ON was slightly worse than that in MS-ON.
Conclusions: Though the ON-lesions were the longest and most prominent in MOG-ON, visual prognoses were much better with almost full recovery in them.
Disclosure: All of the authors has nothing to disclose for this presentation.
Abstract: P377
Type: Poster
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Background: The most common clinical manifestation in demyelinating disorder with serum anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody has been revealed to be optic neuritis (ON). However, its characteristics in optic MRI and visual prognosis, compared to optic neuritis in other demyelinating disorders like multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD), are not fully known.
Methods: We retrospectively collected 69 MS patients with ON history (MS-ON; 75 ON-eyes), 23 NMOSD patients with ON history (NMOSD-ON; 27 ON-eyes), and 17 anti-MOG-Ab (+) patients with ON history (MOG-ON; 24 ON-eyes), all of whom visited and were followed up in Tohoku University Hospital between 2005 and 2015. The following information was collected: sex, onset age of ON, distribution of ON-lesions, ON-lesion length, nadir of visual acuity (VA) in the acute phase, and the latest VA in the chronic phase.
Results: The onset age of ON was higher in NMOSD-ON. ON-lesion lengths in the acute phase were not significantly different among the three subtypes, though MOG-ON showed slightly longer ON-lesions. Intra-orbital lesions were the most frequent in MS-ON and NMOSD-ON, but intra-cranial lesions without chiasmal lesions were the most frequent in MOG-ON. The appearance of ON-lesions in the acute phase was the longest and most prominent in MOG-ON with severe swelling and meandering. Nadirs of VA in the acute phase were not significantly different among the three subtypes, but the latest VA in the chronic phase was significantly better in MOG-ON with almost full-recoveries. The visual prognosis in NMOSD-ON was slightly worse than that in MS-ON.
Conclusions: Though the ON-lesions were the longest and most prominent in MOG-ON, visual prognoses were much better with almost full recovery in them.
Disclosure: All of the authors has nothing to disclose for this presentation.