Contributions
Abstract: P366
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS) is a disease evaluated by EDSS. Critical EDSS changes/thresholds are primarily driven by walking/motor ability in people with MS (PwMS). Functional ability/independence separate from walking is critical when evaluating PwMS disease burden. Although EDSS is primarily a walking scale, hand function represents an independent factor impacting functional ability and independence. EDSS scores strongly correlate with the patient reported outcome patient-reported disease progression (PRO-PDDS).
Objective: To investigate the relationship between in PwMS PRO-PDDS and PRO-hand function and PRO-tremor/coordination and evaluate how these PRO correlate to self-reported quality of life (QoL).
Methods: PwMS completed standardized PRO questionnaires for hand function, tremor/coordination, and Likert QoL during routine care. Regression analyses to investigate: relationship between hand function and tremor/coordination, PRO-PDDS and PRO-QoL; and multivariate regression to investigate: the relationship of hand function and tremor/coordination with PRO-QoL. PDDS scores were grouped: mild-PDDS (0-1), moderate-PDDS (2-4), severe-PDDS (>4). Percent variability of PRO-hand function and PRO-tremor/coordination were analyzed within each PRO-PDDS group, and % overlap of hand function and tremor/coordination was analyzed across PRO-PDDS groups.
Results: 783 PwMS (73.7% female, average age = 49.3±11.2). PRO-hand function and PRO-tremor/coordination correlated (r=0.59, p=< 0.01) and both PRO-Hand function and PRO-tremor/coordination correlated with QoL
(r=0.38, p=< 0.01). PDDS correlated with QoL (r=0.38, p=< 0.01). However, PRO-hand function scores showed great variability: >100% (low-PDDS), 71.3% (moderate-PDDS), and 72.6% (severe-PDDS); average overlap of 55.7% between adjacent PDDS-groups, and 33.9% overlap between extreme PDDS-groups. PRO-Tremor/coordination scores also demonstrated >100% variability (low-PDDS), 66.5% (moderate-PDDS), and 68.1% (severe-PDDS), average overlap of 52.3% between adjacent PDDS-groups, and 32.1% overlap between extreme PDDS-groups.
Conclusions: Hand function, tremor/coordination and PDDS are all factors that significantly relate to self-reported QoL. However, PRO-PDDS is a scale that is insensitive to PRO-hand function and PRO-tremor/coordination. The use PRO-PDDS as an important measure of global disability in PwMS should be reconsidered.
Disclosure: All: nothing to disclose
Abstract: P366
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS) is a disease evaluated by EDSS. Critical EDSS changes/thresholds are primarily driven by walking/motor ability in people with MS (PwMS). Functional ability/independence separate from walking is critical when evaluating PwMS disease burden. Although EDSS is primarily a walking scale, hand function represents an independent factor impacting functional ability and independence. EDSS scores strongly correlate with the patient reported outcome patient-reported disease progression (PRO-PDDS).
Objective: To investigate the relationship between in PwMS PRO-PDDS and PRO-hand function and PRO-tremor/coordination and evaluate how these PRO correlate to self-reported quality of life (QoL).
Methods: PwMS completed standardized PRO questionnaires for hand function, tremor/coordination, and Likert QoL during routine care. Regression analyses to investigate: relationship between hand function and tremor/coordination, PRO-PDDS and PRO-QoL; and multivariate regression to investigate: the relationship of hand function and tremor/coordination with PRO-QoL. PDDS scores were grouped: mild-PDDS (0-1), moderate-PDDS (2-4), severe-PDDS (>4). Percent variability of PRO-hand function and PRO-tremor/coordination were analyzed within each PRO-PDDS group, and % overlap of hand function and tremor/coordination was analyzed across PRO-PDDS groups.
Results: 783 PwMS (73.7% female, average age = 49.3±11.2). PRO-hand function and PRO-tremor/coordination correlated (r=0.59, p=< 0.01) and both PRO-Hand function and PRO-tremor/coordination correlated with QoL
(r=0.38, p=< 0.01). PDDS correlated with QoL (r=0.38, p=< 0.01). However, PRO-hand function scores showed great variability: >100% (low-PDDS), 71.3% (moderate-PDDS), and 72.6% (severe-PDDS); average overlap of 55.7% between adjacent PDDS-groups, and 33.9% overlap between extreme PDDS-groups. PRO-Tremor/coordination scores also demonstrated >100% variability (low-PDDS), 66.5% (moderate-PDDS), and 68.1% (severe-PDDS), average overlap of 52.3% between adjacent PDDS-groups, and 32.1% overlap between extreme PDDS-groups.
Conclusions: Hand function, tremor/coordination and PDDS are all factors that significantly relate to self-reported QoL. However, PRO-PDDS is a scale that is insensitive to PRO-hand function and PRO-tremor/coordination. The use PRO-PDDS as an important measure of global disability in PwMS should be reconsidered.
Disclosure: All: nothing to disclose