Contributions
Abstract: P362
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS) is a disease impacting more than EDSS, relapse and MRI changes. People with MS (PwMS) experience reduced Quality of Life (QoL) from: physical and cognitive impairment, fatigue, depression, and loss of independence/employment. EDSS, a scale that primarily reflects walking-motor function, is insensitive to many important factors including cognitive function. Activities of daily living (ADL) ability can impact QoL. EDSS scores intended to reflect a homogenous disease burden, but ADL skills ability might vary within EDSS groups and ADL decline might impact QoL and reflect disease progression but not be reflected by EDSS changes.
Objective: Investigate the relationship between EDSS and ADL ability by use of the physical self-maintenance scale (PSMS), and explore the impact of cognition on PSMS independent of EDSS.
Methods: Retrospective review of PwMS who underwent standardized computerized cognitive testing (NeuroTrax, NT) during routine clinical care and completed PRO-PSMS, and Likert QoL. PwMS EDSS was grouped: 0-2.5(A), 3-4.5(B), and ≥5.0(C).
Results: 191 PwMS (average age 45.3 +/- 10.8, 72.1% female). PwMS-PSMS scores track with EDSS (p< .0001, r=.48,). However, PwMS-PSMS variability within the 3 EDSS groups was: 11%(A), 12%(B), and 23%(C) respectively, but PwMS-PSMS scores overlap between EDSS groups: 52% (A-B) and 31% (B-C) respectively. PwMS-PSMS scores correlated with: QoL (p< .001, r=.225); NT scores: memory (p=.004, r=.207), executive function (p=.001, r=.325), attention (p=.001, r=.295), global cognitive summary score (p< .001, r=.275) and the number of cognitive domains (CD) impaired >1 standard deviation (p< .001, r=.252).
Conclusions: PwMS-PSMS correlates with EDSS and QoL, but there is considerable variability of PSMS within higher EDSS, and different EDSS scores might reflect similar PSMS ability. Cognitive function impacts PSMS ability, whereas EDSS is insensitive to cognitive function. Physical self-maintenance is not solely dependent upon physical ability. Analysis of PwMS disease impact and treatment needs requires information beyond the EDSS.
Disclosure: Glen Doniger is an employee of NeuroTrax Corporation
Abstract: P362
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple Sclerosis (MS) is a disease impacting more than EDSS, relapse and MRI changes. People with MS (PwMS) experience reduced Quality of Life (QoL) from: physical and cognitive impairment, fatigue, depression, and loss of independence/employment. EDSS, a scale that primarily reflects walking-motor function, is insensitive to many important factors including cognitive function. Activities of daily living (ADL) ability can impact QoL. EDSS scores intended to reflect a homogenous disease burden, but ADL skills ability might vary within EDSS groups and ADL decline might impact QoL and reflect disease progression but not be reflected by EDSS changes.
Objective: Investigate the relationship between EDSS and ADL ability by use of the physical self-maintenance scale (PSMS), and explore the impact of cognition on PSMS independent of EDSS.
Methods: Retrospective review of PwMS who underwent standardized computerized cognitive testing (NeuroTrax, NT) during routine clinical care and completed PRO-PSMS, and Likert QoL. PwMS EDSS was grouped: 0-2.5(A), 3-4.5(B), and ≥5.0(C).
Results: 191 PwMS (average age 45.3 +/- 10.8, 72.1% female). PwMS-PSMS scores track with EDSS (p< .0001, r=.48,). However, PwMS-PSMS variability within the 3 EDSS groups was: 11%(A), 12%(B), and 23%(C) respectively, but PwMS-PSMS scores overlap between EDSS groups: 52% (A-B) and 31% (B-C) respectively. PwMS-PSMS scores correlated with: QoL (p< .001, r=.225); NT scores: memory (p=.004, r=.207), executive function (p=.001, r=.325), attention (p=.001, r=.295), global cognitive summary score (p< .001, r=.275) and the number of cognitive domains (CD) impaired >1 standard deviation (p< .001, r=.252).
Conclusions: PwMS-PSMS correlates with EDSS and QoL, but there is considerable variability of PSMS within higher EDSS, and different EDSS scores might reflect similar PSMS ability. Cognitive function impacts PSMS ability, whereas EDSS is insensitive to cognitive function. Physical self-maintenance is not solely dependent upon physical ability. Analysis of PwMS disease impact and treatment needs requires information beyond the EDSS.
Disclosure: Glen Doniger is an employee of NeuroTrax Corporation