Contributions
Abstract: P361
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Disability outcome measures in Multiple Sclerosis (MS) may be too difficult or too long to be performed in the setting of daily clinical practice. Unipedal Stance Test (UST) is a one-minute per leg task that has been validated in elder population and other neurological conditions such as Parkinson´s disease (e.g. risk of falling), and has the advantage of being reliable and easy to perform, with normal population values already available. Its association with MS disability outcomes has been poorly described.
Goals: To explore the association of UST and disability in a cohort of patients with Progressive Multiple Sclerosis (PrMS).
Methods: A prospective cohort of PrMS patients was explored. The average time (right leg UST + left leg UST in seconds divided by 2) was recorded. Demographical and clinical variables including Expanded Disability Status Score (EDSS), Timed 25 Foot Walk Test (T25FWT), Multiple Sclerosis Functional Composite (MSFC), quality of life (Multiple Sclerosis Impact Scale 29-MSIS29), depression (Beck Depression Inventory-BDI) and Fatigue Severity Scale (FSS) were also collected.
Results: Thirty nine (39) PrMS were recruited (21 primary progressive, 18 secondary progressive), mean age 56.2 years, 24 women, mean disease duration 15.5 years, median EDSS 6. Mean UST was 0.82s (range 0 - 4.98) and it was correlated with EDSS (Rho -0.57, p< 0.001), T25WT (r=-0.42, p=0.026) and MSIS29 (r=-0.43, p=0.007), although after adjusting for EDSS, depression and fatigue, correlation with MSIS29 was no longer significant (rp=-0.253, p=0.22). No associations were found between UST and age, gender, primary/secondary progression, disease duration, MSFC, depression or fatigue.
Conclusions: Unipedal Stance Test is a quick and easy to perform task that correlates with disability in PrMS. Although this is an small exploratory study in a highly disabled population, a validation cohort including larger sample size with relapsing remitting MS patients and longitudinal evaluations is needed to asses the utility of including this measure routinely in the daily practice.
Disclosure: Carmen Pinto declare no conflict of interest
Bernardita Soler declare no conflict of interest
Tomás Labbe declare no conflict of interest
Macarena Vasquez declare no conflict of interest
Ana Reyes declare no conflict of interest
Elizabeth Vergara declare no conflict of interest
Daniella Weaver declare no conflict of interest
Patricia Feliu declare no conflict of interest
Reinaldo Uribe declare no conflict of interest
Ethel Ciampi declare no conflict of interest
Claudia Carcamo declare no conflict of interest
Abstract: P361
Type: Poster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Disability outcome measures in Multiple Sclerosis (MS) may be too difficult or too long to be performed in the setting of daily clinical practice. Unipedal Stance Test (UST) is a one-minute per leg task that has been validated in elder population and other neurological conditions such as Parkinson´s disease (e.g. risk of falling), and has the advantage of being reliable and easy to perform, with normal population values already available. Its association with MS disability outcomes has been poorly described.
Goals: To explore the association of UST and disability in a cohort of patients with Progressive Multiple Sclerosis (PrMS).
Methods: A prospective cohort of PrMS patients was explored. The average time (right leg UST + left leg UST in seconds divided by 2) was recorded. Demographical and clinical variables including Expanded Disability Status Score (EDSS), Timed 25 Foot Walk Test (T25FWT), Multiple Sclerosis Functional Composite (MSFC), quality of life (Multiple Sclerosis Impact Scale 29-MSIS29), depression (Beck Depression Inventory-BDI) and Fatigue Severity Scale (FSS) were also collected.
Results: Thirty nine (39) PrMS were recruited (21 primary progressive, 18 secondary progressive), mean age 56.2 years, 24 women, mean disease duration 15.5 years, median EDSS 6. Mean UST was 0.82s (range 0 - 4.98) and it was correlated with EDSS (Rho -0.57, p< 0.001), T25WT (r=-0.42, p=0.026) and MSIS29 (r=-0.43, p=0.007), although after adjusting for EDSS, depression and fatigue, correlation with MSIS29 was no longer significant (rp=-0.253, p=0.22). No associations were found between UST and age, gender, primary/secondary progression, disease duration, MSFC, depression or fatigue.
Conclusions: Unipedal Stance Test is a quick and easy to perform task that correlates with disability in PrMS. Although this is an small exploratory study in a highly disabled population, a validation cohort including larger sample size with relapsing remitting MS patients and longitudinal evaluations is needed to asses the utility of including this measure routinely in the daily practice.
Disclosure: Carmen Pinto declare no conflict of interest
Bernardita Soler declare no conflict of interest
Tomás Labbe declare no conflict of interest
Macarena Vasquez declare no conflict of interest
Ana Reyes declare no conflict of interest
Elizabeth Vergara declare no conflict of interest
Daniella Weaver declare no conflict of interest
Patricia Feliu declare no conflict of interest
Reinaldo Uribe declare no conflict of interest
Ethel Ciampi declare no conflict of interest
Claudia Carcamo declare no conflict of interest