Contributions
Abstract: P339
Type: Poster
Abstract Category: Clinical aspects of MS - MS symptoms
Background: RLS is a sensorimotor disorder characterised by a distressing urge to move the legs usually associated with uncomfortable sensation. We aim to examine the prevalence of RLS symptoms in MS patients, as the fulfillment of at least 2 of the 4 essential requirements included in the diagnostic criteria for RLS (Allen RP, 2003). We also evaluate the possible risk factors and clinical implications.
Material and methods: We enrolled consecutive, unrelated MS patients diagnosed according to the McDonald-criteria-2010. We excluded patients with other neurologic diseases or conditions associated with an increased risk of RLS (iron deficiency, renal failure, etc.). We used validated questionnaires to analyse the presence of RLS, its severity, possible risk factors and clinical impact (demographic variables, clinical forms of MS, EDSS, insomnia, fatigue, sleepiness, anxiety, depression, quality of life).
Results: We included 120 MS patients (65.8% women), with a mean age of 39 years and a mean follow-up of 83 months. Thirty-four patients (28.33%) met at least two of the requirements of the RLS diagnostic criteria, all of them with a moderate to severe severity.
Anxiety (p< 0.001), depression (p = 0.001), pain (p = 0.002), a relapse in the previous three months (p< 0.001) and disease duration (p=0.001) were associated with RLS in MS patients in univariate analyses. Multivariate logistical regression model showed that a recent relapse (p=0.012, OR 7.51 [IC:1.51-36.30]) and a shorter disease duration (p = 0.004, OR 0.98 [IC:0.97-0.99]) were associated with RLS symptoms.
Finally, RLS symptoms may cause insomnia (p = 0.001), sleepiness (p = 0.01), cognitive impairment (p = 0.038) and poor quality of life (p = 0.037) in MS patients.
Conclusions: The appearance of symptoms of RLS is common in patients with MS, usually with moderate-severe degree, causing an important comorbidity. Early identification and treatment of this sleep disorder may improve quality of life in MS patients.
Disclosure:
L. Lebrato Hernández: nothing to disclose.
M. Díaz Sánchez: nothing to disclose.
M. Prieto León: nothing to disclose.
N. Cerdá Fuertes: nothing to disclose.
JL. Casado Chocán: nothing to disclose.
AJ. Uclés Sánchez: nothing to disclose.
Abstract: P339
Type: Poster
Abstract Category: Clinical aspects of MS - MS symptoms
Background: RLS is a sensorimotor disorder characterised by a distressing urge to move the legs usually associated with uncomfortable sensation. We aim to examine the prevalence of RLS symptoms in MS patients, as the fulfillment of at least 2 of the 4 essential requirements included in the diagnostic criteria for RLS (Allen RP, 2003). We also evaluate the possible risk factors and clinical implications.
Material and methods: We enrolled consecutive, unrelated MS patients diagnosed according to the McDonald-criteria-2010. We excluded patients with other neurologic diseases or conditions associated with an increased risk of RLS (iron deficiency, renal failure, etc.). We used validated questionnaires to analyse the presence of RLS, its severity, possible risk factors and clinical impact (demographic variables, clinical forms of MS, EDSS, insomnia, fatigue, sleepiness, anxiety, depression, quality of life).
Results: We included 120 MS patients (65.8% women), with a mean age of 39 years and a mean follow-up of 83 months. Thirty-four patients (28.33%) met at least two of the requirements of the RLS diagnostic criteria, all of them with a moderate to severe severity.
Anxiety (p< 0.001), depression (p = 0.001), pain (p = 0.002), a relapse in the previous three months (p< 0.001) and disease duration (p=0.001) were associated with RLS in MS patients in univariate analyses. Multivariate logistical regression model showed that a recent relapse (p=0.012, OR 7.51 [IC:1.51-36.30]) and a shorter disease duration (p = 0.004, OR 0.98 [IC:0.97-0.99]) were associated with RLS symptoms.
Finally, RLS symptoms may cause insomnia (p = 0.001), sleepiness (p = 0.01), cognitive impairment (p = 0.038) and poor quality of life (p = 0.037) in MS patients.
Conclusions: The appearance of symptoms of RLS is common in patients with MS, usually with moderate-severe degree, causing an important comorbidity. Early identification and treatment of this sleep disorder may improve quality of life in MS patients.
Disclosure:
L. Lebrato Hernández: nothing to disclose.
M. Díaz Sánchez: nothing to disclose.
M. Prieto León: nothing to disclose.
N. Cerdá Fuertes: nothing to disclose.
JL. Casado Chocán: nothing to disclose.
AJ. Uclés Sánchez: nothing to disclose.