Contributions
Abstract: P308
Type: Poster
Abstract Category: Clinical aspects of MS - Epidemiology
Background: People with Multiple Sclerosis (MS), a chronic neurological disorder, often experience progressive physical disability, fatigue, pain, depression and a range of other mental and physical symptoms negatively impacting on their quality of life (QOL). The physical and mental health related QOL of people with MS is increasingly recognised as a key outcome in clinical studies, and may predict the course of disability progression. Modifiable lifestyle factors, such as smoking, physical activity and vitamin D, play a significant role in the development and progression of MS. Few studies to date have looked at associations of a comprehensive suite of modifiable factors lifestyle and QOL.
Methods: Using patient-reported data from 2312 people with MS, regression models incorporating socio-demographic, clinical and lifestyle factors were used to predict associations with mental and physical QOL, measured with the Multiple Sclerosis Quality of Life (MSQOL-54) Instrument.
Results: Participants were on average 45.6 years old, 82.4% were women, from 54 countries around the world, mostly with a partner (74.1%), and with a university degree (59.5%).
Several modifiable factors were associated with physical and mental health composite (PHC and MHC) of the MSQOL-54. While controlling for socio-demographic factors and level of disability, low, compared to moderate and high physical activity, was associated with a 6 and 10 points lower score on the PHC and 3-4 and 6 points lower score on the MHC respectively; not smoking versus currently smoking was associated with 4-5 points higher PHC and 7 point higher MHC; improvement in diet of 20/100 points was associated with a 3 point higher PHC and 5 point higher MHC. Body mass index, number of comorbidities, meditation frequency, omega 3 and vitamin D supplementation showed significant, but small, associations, while alcohol intake did not.
Conclusion: The associations between modifiable lifestyle factors and QOL suggest there is potential for secondary prevention of the known deterioration of QOL for people with MS through lifestyle risk factor modification.
Disclosure: The Bloom Foundation and the Horne Family Charitable Trust supported this study
Claudia H Marck, nothing to disclose
Alysha M De Livera, nothing to disclose
Chelsea Brown, nothing to disclose
Sandra L Neate, nothing to disclose
Keryn L Taylor facilitates educational lifestyle interventions for people with MS
Tracey J Weiland, nothing to disclose
George A Jelinek receives royalties from his book "Overcoming Multiple Sclerosis".
Abstract: P308
Type: Poster
Abstract Category: Clinical aspects of MS - Epidemiology
Background: People with Multiple Sclerosis (MS), a chronic neurological disorder, often experience progressive physical disability, fatigue, pain, depression and a range of other mental and physical symptoms negatively impacting on their quality of life (QOL). The physical and mental health related QOL of people with MS is increasingly recognised as a key outcome in clinical studies, and may predict the course of disability progression. Modifiable lifestyle factors, such as smoking, physical activity and vitamin D, play a significant role in the development and progression of MS. Few studies to date have looked at associations of a comprehensive suite of modifiable factors lifestyle and QOL.
Methods: Using patient-reported data from 2312 people with MS, regression models incorporating socio-demographic, clinical and lifestyle factors were used to predict associations with mental and physical QOL, measured with the Multiple Sclerosis Quality of Life (MSQOL-54) Instrument.
Results: Participants were on average 45.6 years old, 82.4% were women, from 54 countries around the world, mostly with a partner (74.1%), and with a university degree (59.5%).
Several modifiable factors were associated with physical and mental health composite (PHC and MHC) of the MSQOL-54. While controlling for socio-demographic factors and level of disability, low, compared to moderate and high physical activity, was associated with a 6 and 10 points lower score on the PHC and 3-4 and 6 points lower score on the MHC respectively; not smoking versus currently smoking was associated with 4-5 points higher PHC and 7 point higher MHC; improvement in diet of 20/100 points was associated with a 3 point higher PHC and 5 point higher MHC. Body mass index, number of comorbidities, meditation frequency, omega 3 and vitamin D supplementation showed significant, but small, associations, while alcohol intake did not.
Conclusion: The associations between modifiable lifestyle factors and QOL suggest there is potential for secondary prevention of the known deterioration of QOL for people with MS through lifestyle risk factor modification.
Disclosure: The Bloom Foundation and the Horne Family Charitable Trust supported this study
Claudia H Marck, nothing to disclose
Alysha M De Livera, nothing to disclose
Chelsea Brown, nothing to disclose
Sandra L Neate, nothing to disclose
Keryn L Taylor facilitates educational lifestyle interventions for people with MS
Tracey J Weiland, nothing to disclose
George A Jelinek receives royalties from his book "Overcoming Multiple Sclerosis".