Contributions
Abstract: P295
Type: Poster
Abstract Category: Clinical aspects of MS - Paediatric MS
Background: A possible role of high-fat diet in the exacerbation of EAE, the animal model for MS has been reported. However, the role of diet in the risk of MS relapse is not known.
Methods: This project stems from an ongoing case-control study of environmental risk factors in pediatric MS at 16 US centers that enrolled patients with CIS or MS with onset before 18 years of age and less than 4 year duration. Dietary fat, vegetable, fiber, fruits, carbohydrates, protein, sugar, dairy, and iron intake in the week before enrollment were assessed using the validated self-reported Block Kids Food Screener (NutritionQuest). Patients who had available prospective relapse data entered in the Pediatric MS Network registry after enrollment in the case-control study were included in this analysis. Multivariate Cox proportional hazard model was used to estimate the hazard ratio and 95% CI of the time to the relapse following study enrollment. The model was adjusted for age, gender, race/ethnicity, body mass index, type of disease-modifying treatment.
Results: 219 patients with early pediatric relapsing-remitting MS were included in this study (61.2% female, 39.3% non-whites, mean age 15.1 years, mean disease duration at enrollment 10.8 months). Median follow-up time after completion of food frequency questionnaire was 1.8 year (0.1-4.1). In multivariable analyses, each 1% increase in energy intake from fat increased the hazard of relapse by 4% (adjusted hazard rate (HR) 1.04, CI:1.0-1.08, p=0.04). Patients with high vegetable intake had a lower hazard of relapses (adjusted HR: 0.58, CI:0.35-0.96, p=0.03). Total energy intake, percent of energy from carbohydrates and proteins, fruits, and fibers were not associated with risk of relapse.
Conclusion: This study suggests that high energy intake from fat may increase the risk of MS relapse in children while vegetable intake may be protective. These findings if confirmed may have direct clinical implications for dietary recommendations for patients with MS.
Disclosure: Authors have no relevant disclosures.
Abstract: P295
Type: Poster
Abstract Category: Clinical aspects of MS - Paediatric MS
Background: A possible role of high-fat diet in the exacerbation of EAE, the animal model for MS has been reported. However, the role of diet in the risk of MS relapse is not known.
Methods: This project stems from an ongoing case-control study of environmental risk factors in pediatric MS at 16 US centers that enrolled patients with CIS or MS with onset before 18 years of age and less than 4 year duration. Dietary fat, vegetable, fiber, fruits, carbohydrates, protein, sugar, dairy, and iron intake in the week before enrollment were assessed using the validated self-reported Block Kids Food Screener (NutritionQuest). Patients who had available prospective relapse data entered in the Pediatric MS Network registry after enrollment in the case-control study were included in this analysis. Multivariate Cox proportional hazard model was used to estimate the hazard ratio and 95% CI of the time to the relapse following study enrollment. The model was adjusted for age, gender, race/ethnicity, body mass index, type of disease-modifying treatment.
Results: 219 patients with early pediatric relapsing-remitting MS were included in this study (61.2% female, 39.3% non-whites, mean age 15.1 years, mean disease duration at enrollment 10.8 months). Median follow-up time after completion of food frequency questionnaire was 1.8 year (0.1-4.1). In multivariable analyses, each 1% increase in energy intake from fat increased the hazard of relapse by 4% (adjusted hazard rate (HR) 1.04, CI:1.0-1.08, p=0.04). Patients with high vegetable intake had a lower hazard of relapses (adjusted HR: 0.58, CI:0.35-0.96, p=0.03). Total energy intake, percent of energy from carbohydrates and proteins, fruits, and fibers were not associated with risk of relapse.
Conclusion: This study suggests that high energy intake from fat may increase the risk of MS relapse in children while vegetable intake may be protective. These findings if confirmed may have direct clinical implications for dietary recommendations for patients with MS.
Disclosure: Authors have no relevant disclosures.