Contributions
Abstract: P288
Type: Poster
Abstract Category: Clinical aspects of MS - Paediatric MS
Background: Clinically Isolated Syndrome (CIS) is a first demyelinating event of the CNS and can be a single event. After CIS a chronic disease course with ongoing inflammation and relapses might occur, resulting in a diagnosis of multiple sclerosis (MS). Whether children and adults with CIS have the same disease course has not been prospectively explored yet.
Methods: Patients with CIS, whose age ranged from 1-50 years, were prospectively followed. We divided the patients in four different age groups: patients 1-10, 11-16, 17-29, and 30-50 years old. Among these groups demographic data, disease course, time to MS diagnosis and annualised relapse rates (ARR) were compared.
Results: We included 383 CIS patients, of whom 218 (56.9%) were diagnosed with MS. 11-16 year-old children had the highest rate of MS conversion (85% versus 51% in the other age groups together, p< 0.01) and the shortest time to MS diagnosis (median time 2.6 months (IQR: 0.62-5.94) versus 7.8 months (IQR: 2.0-25.5) in the other age groups together, p< 0.01). Highest ARR were found in 1-10 year-old children with MS (ARR: 0.79), followed by 11-16 year-old children with MS (ARR: 0.62). In 30-50 year-old adults with MS the ARR was 0.41.
Conclusion: Children with CIS tend to have a more inflammatory disease course appearing from the high relapse rate in all children, and the highest rate of MS conversion in 11-16 year-old children. This supports early initiation of first-line disease modifying therapy in children with CIS who are at high risk for a future MS diagnosis.
Disclosure:
RM van der Vuurst de Vries: nothing to disclose
ED van Pelt: nothing to disclose
JM Mescheriakova: nothing to disclose
YYM Wong: nothing to disclose
IA Ketelslegers: nothing to disclose
TAM Siepman: nothing to disclose
CE Catsman-Berrevoets: nothing to disclose
RF Neuteboom: nothing to disclose
RQ Hintzen: nothing to disclose.
Abstract: P288
Type: Poster
Abstract Category: Clinical aspects of MS - Paediatric MS
Background: Clinically Isolated Syndrome (CIS) is a first demyelinating event of the CNS and can be a single event. After CIS a chronic disease course with ongoing inflammation and relapses might occur, resulting in a diagnosis of multiple sclerosis (MS). Whether children and adults with CIS have the same disease course has not been prospectively explored yet.
Methods: Patients with CIS, whose age ranged from 1-50 years, were prospectively followed. We divided the patients in four different age groups: patients 1-10, 11-16, 17-29, and 30-50 years old. Among these groups demographic data, disease course, time to MS diagnosis and annualised relapse rates (ARR) were compared.
Results: We included 383 CIS patients, of whom 218 (56.9%) were diagnosed with MS. 11-16 year-old children had the highest rate of MS conversion (85% versus 51% in the other age groups together, p< 0.01) and the shortest time to MS diagnosis (median time 2.6 months (IQR: 0.62-5.94) versus 7.8 months (IQR: 2.0-25.5) in the other age groups together, p< 0.01). Highest ARR were found in 1-10 year-old children with MS (ARR: 0.79), followed by 11-16 year-old children with MS (ARR: 0.62). In 30-50 year-old adults with MS the ARR was 0.41.
Conclusion: Children with CIS tend to have a more inflammatory disease course appearing from the high relapse rate in all children, and the highest rate of MS conversion in 11-16 year-old children. This supports early initiation of first-line disease modifying therapy in children with CIS who are at high risk for a future MS diagnosis.
Disclosure:
RM van der Vuurst de Vries: nothing to disclose
ED van Pelt: nothing to disclose
JM Mescheriakova: nothing to disclose
YYM Wong: nothing to disclose
IA Ketelslegers: nothing to disclose
TAM Siepman: nothing to disclose
CE Catsman-Berrevoets: nothing to disclose
RF Neuteboom: nothing to disclose
RQ Hintzen: nothing to disclose.