Contributions
Abstract: P282
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Aims: We compared resting state (RS) functional connectivity (FC) within and among RS networks between patients with neuromyelitis optica spectrum disorder (NMOSD, 2015 criteria), isolated recurrent optic neuritis (ON) and recurrent myelitis.
Methods: RS fMRI was acquired from 30 NMOSD, 11 ON, 12 myelitis patients and 30 healthy controls (HC). RS FC within and between the main sensory and motor networks as well as correlations with motor performance were assessed using SPM12.
Results: Compared with HC, NMOSD patients showed decreased RS FC of the secondary visual network. They also showed increased RS FC of the visual and auditory networks vs HC, ON and myelitis. No sensorimotor RS FC abnormalities were detected. ON patients experienced decreased RS FC of the visual and auditory networks and increased RS FC of primary visual regions. Myelitis patients had reduced RS FC of the sensorimotor, visual and auditory networks vs HC, NMOSD and ON. They also showed increased RS FC of the precuneus (sensorimotor network) and cerebellum (visual network). In all groups, decreased RS FC correlated with poor motor performance. In myelitis increased precuneus RS FC correlated with better motor performance. FNC between motor and visual RSNs was increased in NMOSD, while FNC was markedly decreased between primary and secondary visual RSNs in ON.
Conclusions: In recurrent ON and myelitis, abnormal RS FC was observed in networks primarily affected by the pathological process. NMOSD showed decreased visual system RS FC and increased RS FC in other sensory networks, suggesting cross-modal plasticity among different sensory modalities.
Disclosure:
Drs d´Ambrosio, Savoldi, Valsasina, Radaelli, Preziosa, and Falini.
Dr Rocca received speakers honoraria from Biogen Idec, Novartis and ExceMed and receives research support from the Italian Ministry of Health and Fondazione Italiana Sclerosi Multipla.
Prof. Comi has received consulting fees for participating on advisory boards from Novartis, Teva Pharmaceutical Ind. Ltd, Sanofi, Genzyme, Merck Serono, Bayer, Actelion and honorarium for speaking activities for Novartis, Teva Pharmaceutical Ind. Ltd, Sanofi, Genzyme, Merck Serono, Bayer, Biogen, Excemed.
Prof. Filippi is Editor-in-Chief of the Journal of Neurology; serves on scientific advisory boards for Teva Pharmaceutical Industries; has received compensation for consulting services and/or speaking activities from Biogen Idec, Excemed, Novartis, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Teva Pharmaceutical Industries, Novartis, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, Cure PSP, Alzheimer´s Drug Discovery Foundation (ADDF), the Jacques and Gloria Gossweiler Foundation (Switzerland), and ARiSLA (Fondazione Italiana di Ricerca per la SLA).
Abstract: P282
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Aims: We compared resting state (RS) functional connectivity (FC) within and among RS networks between patients with neuromyelitis optica spectrum disorder (NMOSD, 2015 criteria), isolated recurrent optic neuritis (ON) and recurrent myelitis.
Methods: RS fMRI was acquired from 30 NMOSD, 11 ON, 12 myelitis patients and 30 healthy controls (HC). RS FC within and between the main sensory and motor networks as well as correlations with motor performance were assessed using SPM12.
Results: Compared with HC, NMOSD patients showed decreased RS FC of the secondary visual network. They also showed increased RS FC of the visual and auditory networks vs HC, ON and myelitis. No sensorimotor RS FC abnormalities were detected. ON patients experienced decreased RS FC of the visual and auditory networks and increased RS FC of primary visual regions. Myelitis patients had reduced RS FC of the sensorimotor, visual and auditory networks vs HC, NMOSD and ON. They also showed increased RS FC of the precuneus (sensorimotor network) and cerebellum (visual network). In all groups, decreased RS FC correlated with poor motor performance. In myelitis increased precuneus RS FC correlated with better motor performance. FNC between motor and visual RSNs was increased in NMOSD, while FNC was markedly decreased between primary and secondary visual RSNs in ON.
Conclusions: In recurrent ON and myelitis, abnormal RS FC was observed in networks primarily affected by the pathological process. NMOSD showed decreased visual system RS FC and increased RS FC in other sensory networks, suggesting cross-modal plasticity among different sensory modalities.
Disclosure:
Drs d´Ambrosio, Savoldi, Valsasina, Radaelli, Preziosa, and Falini.
Dr Rocca received speakers honoraria from Biogen Idec, Novartis and ExceMed and receives research support from the Italian Ministry of Health and Fondazione Italiana Sclerosi Multipla.
Prof. Comi has received consulting fees for participating on advisory boards from Novartis, Teva Pharmaceutical Ind. Ltd, Sanofi, Genzyme, Merck Serono, Bayer, Actelion and honorarium for speaking activities for Novartis, Teva Pharmaceutical Ind. Ltd, Sanofi, Genzyme, Merck Serono, Bayer, Biogen, Excemed.
Prof. Filippi is Editor-in-Chief of the Journal of Neurology; serves on scientific advisory boards for Teva Pharmaceutical Industries; has received compensation for consulting services and/or speaking activities from Biogen Idec, Excemed, Novartis, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Teva Pharmaceutical Industries, Novartis, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, Cure PSP, Alzheimer´s Drug Discovery Foundation (ADDF), the Jacques and Gloria Gossweiler Foundation (Switzerland), and ARiSLA (Fondazione Italiana di Ricerca per la SLA).