Contributions
Abstract: P279
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction and background: NMOSD and multiple sclerosis (MS) are both relapsing central nervous system (CNS) inflamatory disease with similar clinical features at the beggining. Cognitive decline is often present in MS, even since early stages, and seems to correlate with brain atrophy, therefore with a neurodegenerative process independent on number of relapses. Until now, there are very few and controversy evidences of cognitive impairmenti n NMOSD and not evidence of global axonal degeneration out of relapses.
Methods: NMOSD patients were recruited from a reference Multiple Sclerosis Center. Cross-sectional study was carried out. A wide batery of specific neuropsychological tests was used to evaluate every cognitive domain: concentration/attention (Verbal Span, PASAT), language (ACE-III subtest), basic and complex executive function (SDMT, A and B form of TMT, categorial and formal recall), memory (FCSR, FCRO), visuospatial and visuoperceptive function (VOSP, Benton JLO) and also depression and fatigue scales. Cognitive impairment was diagnosed when low scores were yielded in two tests for an specific domain (adjusted by level of education and age), at least in two different domains.
Results: Ten patients were examinated, with a median age of 40 years old (rank 21-69) and a disease duration of 4.42 years (rank 1.75-10.75). The mean EDSS was 3.0 (rank 1.0-6.0). Only one patient (female and 42 years old) meet criteria of cognitive impairment, showing deficiency in executive and visuoperceptive function. Two patients presented decline in frontal execution but no other domain, both associated with mild and moderate deppresion in Beck Inventary Scale (BIS). More than 50% patients showed high levels of fatigue.
Conclusions: Despite long median disease duration of our patients, cognitive impairment was very rare. Mainly affected domains were frontal execution and visuoperceptive function. This results could reflect the absence or low degree of global progressive degeneration in NMOSD patients and could help us to distinguish from MS.
Disclosure:
Aida Orviz García: nothing to disclose
María Valles Salgado: nothing to disclose
Jordi Matías-Guiu Antem: nothing to disclose
Inés González Suárez: nothing to disclose
Celia Oreja-Guevara: nothing to disclose
Abstract: P279
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction and background: NMOSD and multiple sclerosis (MS) are both relapsing central nervous system (CNS) inflamatory disease with similar clinical features at the beggining. Cognitive decline is often present in MS, even since early stages, and seems to correlate with brain atrophy, therefore with a neurodegenerative process independent on number of relapses. Until now, there are very few and controversy evidences of cognitive impairmenti n NMOSD and not evidence of global axonal degeneration out of relapses.
Methods: NMOSD patients were recruited from a reference Multiple Sclerosis Center. Cross-sectional study was carried out. A wide batery of specific neuropsychological tests was used to evaluate every cognitive domain: concentration/attention (Verbal Span, PASAT), language (ACE-III subtest), basic and complex executive function (SDMT, A and B form of TMT, categorial and formal recall), memory (FCSR, FCRO), visuospatial and visuoperceptive function (VOSP, Benton JLO) and also depression and fatigue scales. Cognitive impairment was diagnosed when low scores were yielded in two tests for an specific domain (adjusted by level of education and age), at least in two different domains.
Results: Ten patients were examinated, with a median age of 40 years old (rank 21-69) and a disease duration of 4.42 years (rank 1.75-10.75). The mean EDSS was 3.0 (rank 1.0-6.0). Only one patient (female and 42 years old) meet criteria of cognitive impairment, showing deficiency in executive and visuoperceptive function. Two patients presented decline in frontal execution but no other domain, both associated with mild and moderate deppresion in Beck Inventary Scale (BIS). More than 50% patients showed high levels of fatigue.
Conclusions: Despite long median disease duration of our patients, cognitive impairment was very rare. Mainly affected domains were frontal execution and visuoperceptive function. This results could reflect the absence or low degree of global progressive degeneration in NMOSD patients and could help us to distinguish from MS.
Disclosure:
Aida Orviz García: nothing to disclose
María Valles Salgado: nothing to disclose
Jordi Matías-Guiu Antem: nothing to disclose
Inés González Suárez: nothing to disclose
Celia Oreja-Guevara: nothing to disclose