Contributions
Abstract: P278
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: The "atypical" myelitis of multiple sclerosis (MS), are characterized by longitudinally extensive myelitis (affecting >3 vertebral segments, transverse myelitis (> 50% of spinal cord in the axial plane), anterior, or central cord lesions.
The aim of this study is to collect atypical cases of myelitis related to MS to better characterize this population.
Methods: This study is observational, retrospective, multicenter, and includes incident cases between 2012 and 2016. Ten patients were included in Strasbourg, Nice and Montpellier in France.
We collected demographic information, clinical and radiological characteristics of myelitis, laboratory results including CSF, brain IRM, treatment, and clinical follow-up.
Results: All patients fulfilled 2010 Macdonald criteria. The mean age was 40,4 years, the sex ratio woman / man was 1,5/1. Myelitis was the first relapse for 8 patients and the second for 2 patients. Intrathecal synthesis of immunoglobulin was found in all cases. On spinal cord MRI, we observed 4 longitudinally extensive myelitis, 6 transverse myelitis, 2 central cord lesions and 2 transverse and longitudinally extensive myelitis. The median EDSS was 4 [1-8] during the relapse, 3 [0-6,5] after 6 months and 3 [0-7] after a mean follow-up of 3 +/- 10 years.
Myelitis occurred as a second relapse for 3 patients. Three patients experienced a progressive course of the disease. Three other patients had not new symptoms and one patient had a cerebellar peduncle lesion.
Discussion: the small size of our cohort is a consequent of the rarity of this clinical manifestation in MS. Extensive myelitis represents the main manifestation in our cohort. A better recovery than in the neuromyelitis optica spectrum or the systemic diseases seems to emerge.
Conclusion: The atypical presentation of myelitis in MS is mainly characterized by longitudinally and transverse extensive myelitis. It seems to be a specific entity as defined by its disease course and its potential for recovery.
Disclosure: Nothing to disclose
Abstract: P278
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: The "atypical" myelitis of multiple sclerosis (MS), are characterized by longitudinally extensive myelitis (affecting >3 vertebral segments, transverse myelitis (> 50% of spinal cord in the axial plane), anterior, or central cord lesions.
The aim of this study is to collect atypical cases of myelitis related to MS to better characterize this population.
Methods: This study is observational, retrospective, multicenter, and includes incident cases between 2012 and 2016. Ten patients were included in Strasbourg, Nice and Montpellier in France.
We collected demographic information, clinical and radiological characteristics of myelitis, laboratory results including CSF, brain IRM, treatment, and clinical follow-up.
Results: All patients fulfilled 2010 Macdonald criteria. The mean age was 40,4 years, the sex ratio woman / man was 1,5/1. Myelitis was the first relapse for 8 patients and the second for 2 patients. Intrathecal synthesis of immunoglobulin was found in all cases. On spinal cord MRI, we observed 4 longitudinally extensive myelitis, 6 transverse myelitis, 2 central cord lesions and 2 transverse and longitudinally extensive myelitis. The median EDSS was 4 [1-8] during the relapse, 3 [0-6,5] after 6 months and 3 [0-7] after a mean follow-up of 3 +/- 10 years.
Myelitis occurred as a second relapse for 3 patients. Three patients experienced a progressive course of the disease. Three other patients had not new symptoms and one patient had a cerebellar peduncle lesion.
Discussion: the small size of our cohort is a consequent of the rarity of this clinical manifestation in MS. Extensive myelitis represents the main manifestation in our cohort. A better recovery than in the neuromyelitis optica spectrum or the systemic diseases seems to emerge.
Conclusion: The atypical presentation of myelitis in MS is mainly characterized by longitudinally and transverse extensive myelitis. It seems to be a specific entity as defined by its disease course and its potential for recovery.
Disclosure: Nothing to disclose