Contributions
Abstract: P276
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: The clinical course of primary progressive multiple sclerosis (PPMS) is highly variable and unpredictable. In some patients, disability progresses fast causing deterioration within few years, while in others progression is fairly slowly. In the current study we analyzed different progression rates and associated demographic and clinical parameters in a large PPMS cohort.
Methods: We divided PPMS patients with a long-follow-up into sub-groups according to the time from onset they reached neurological disability by the Expanded Disability Status Scale (EDSS) of at least 3.0. PPMS patients that progressed to EDSS≥3.0 within 2 years from onset were defined as Fast progressing; those that reached EDSS≥3.0 within 5 years or later were defined as Slow progressing, and patients that attained EDSS≥3.0 between 2 to 5 years from onset were defined as Intermediate progressing. In the Fast progressing group, patients that further progressed to EDSS≥6.0 within 5 years were defined as Persistently Fast progressing. In the Slow progressing group patients reaching EDSS≥6 within 10 years were defined as Persistently Slow progressing. Clinical and demographical parameters at onset were compared between the groups.
Result: Progression rates of 163 PPMS patients, age at onset 40.9±10.6 years, 53.4% males, were analyzed. The Fast progressing patients represent 53% and the Slow progressing patients 26% of the PPMS population. Persistently Fast and Persistently Slow progressing patients represent 16% and 21% of the PPMS population. Both Fast progressing and Persistently Fast progressing groups are characterized by significantly higher EDSS at onset as compared to Slow and Persistently Slow progressing patients, p< 0.001. This difference in disability was associated with higher proportion of pyramidal, cerebellar and visual deficits at onset.
Conclusions: PPMS patients present with different rates of progression. Fast clinical progression is more common and is associated with higher disability at onset.
Disclosure:
Legarda Carolina has nothing to disclose
Gurevich Michael has nothing to disclose
Magalashvili David has nothing to disclose
Dolev Mark has nothing to disclose
Achiron Anat received personal compensation from Teva Pharmaceutical Industries, Sanofi-Genzyme and Novartis for serving on scientific advisory board and as a consultant.
Abstract: P276
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background: The clinical course of primary progressive multiple sclerosis (PPMS) is highly variable and unpredictable. In some patients, disability progresses fast causing deterioration within few years, while in others progression is fairly slowly. In the current study we analyzed different progression rates and associated demographic and clinical parameters in a large PPMS cohort.
Methods: We divided PPMS patients with a long-follow-up into sub-groups according to the time from onset they reached neurological disability by the Expanded Disability Status Scale (EDSS) of at least 3.0. PPMS patients that progressed to EDSS≥3.0 within 2 years from onset were defined as Fast progressing; those that reached EDSS≥3.0 within 5 years or later were defined as Slow progressing, and patients that attained EDSS≥3.0 between 2 to 5 years from onset were defined as Intermediate progressing. In the Fast progressing group, patients that further progressed to EDSS≥6.0 within 5 years were defined as Persistently Fast progressing. In the Slow progressing group patients reaching EDSS≥6 within 10 years were defined as Persistently Slow progressing. Clinical and demographical parameters at onset were compared between the groups.
Result: Progression rates of 163 PPMS patients, age at onset 40.9±10.6 years, 53.4% males, were analyzed. The Fast progressing patients represent 53% and the Slow progressing patients 26% of the PPMS population. Persistently Fast and Persistently Slow progressing patients represent 16% and 21% of the PPMS population. Both Fast progressing and Persistently Fast progressing groups are characterized by significantly higher EDSS at onset as compared to Slow and Persistently Slow progressing patients, p< 0.001. This difference in disability was associated with higher proportion of pyramidal, cerebellar and visual deficits at onset.
Conclusions: PPMS patients present with different rates of progression. Fast clinical progression is more common and is associated with higher disability at onset.
Disclosure:
Legarda Carolina has nothing to disclose
Gurevich Michael has nothing to disclose
Magalashvili David has nothing to disclose
Dolev Mark has nothing to disclose
Achiron Anat received personal compensation from Teva Pharmaceutical Industries, Sanofi-Genzyme and Novartis for serving on scientific advisory board and as a consultant.