Contributions
Abstract: P274
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background and objective: Depression in chronic neuroinflammatory diseases are common, and regarded as a major burden of disease. About 25 to 50% of patients with multiple sclerosis (MS) develop a type of depression over the disease course. And the factors that affect the depression have been studied well; disease duration and fatigue were related closely. However, the issues of depression are largely unknown in patients with neuromyelitis optica spectrum disorder (NMOSD). We aimed to elucidate the depression and its contributory factors in patients with NMOSD.
Methods: We prospectively studied NMOSD patients who were in remission and seropositive for aquaporin-4 antibody. Depression and health-related quality of life were evaluated in enrolled patients, using the revised Beck Depression Inventory (BDI-II) and the short form 36 health survey questionnaire version 2 (SF-36v2), respectively. Demographic and clinical findings of enrolled patients were reviewed.
Results: A total of 33 patients were evaluated (28 females; age, 47.2 ± 13.7 years). The median EDSS score was 2.0 (range 0 to 8.0). 51.5% of NMOSD patients were depressed, having 14 or more of BDI-II score. And the BDI-II score correlated positively with Expanded disability status scale (EDSS) (r = 0.433, p = 0.012) but not associated with the disease duration or the location of central nervous system (CNS) involvement. There were significant correlations between health-related quality of life score by SF-36v2 and depression by BDI-II score (mental component score: r = -0.617, p < 0.001; physical component score: r = -0.449, p = 0.010). Multiple linear regression analysis showed that the degree of depression was independently associated with mental health summary scale of SF-36v2 (B=−0.875; 95%CI −1.372 to −0.377; p = 0.001).
Conclusion: Our study suggested that the depression was common, and had a significant impact on the mental quality of life in patients with NMOSD.
Disclosure:
J.M.S: Nothing to disclose
M.C: Nothing to disclose
Y.S.K: Nothing to disclose
E.B.C: Nothing to disclose
H.L.L: Nothing to disclose
S.Y.K: Nothing to disclose
K.H.L: Nothing to disclose
B.J.K: Nothing to disclose
J.H.M: Nothing to disclose
Abstract: P274
Type: Poster
Abstract Category: Clinical aspects of MS - MS Variants
Background and objective: Depression in chronic neuroinflammatory diseases are common, and regarded as a major burden of disease. About 25 to 50% of patients with multiple sclerosis (MS) develop a type of depression over the disease course. And the factors that affect the depression have been studied well; disease duration and fatigue were related closely. However, the issues of depression are largely unknown in patients with neuromyelitis optica spectrum disorder (NMOSD). We aimed to elucidate the depression and its contributory factors in patients with NMOSD.
Methods: We prospectively studied NMOSD patients who were in remission and seropositive for aquaporin-4 antibody. Depression and health-related quality of life were evaluated in enrolled patients, using the revised Beck Depression Inventory (BDI-II) and the short form 36 health survey questionnaire version 2 (SF-36v2), respectively. Demographic and clinical findings of enrolled patients were reviewed.
Results: A total of 33 patients were evaluated (28 females; age, 47.2 ± 13.7 years). The median EDSS score was 2.0 (range 0 to 8.0). 51.5% of NMOSD patients were depressed, having 14 or more of BDI-II score. And the BDI-II score correlated positively with Expanded disability status scale (EDSS) (r = 0.433, p = 0.012) but not associated with the disease duration or the location of central nervous system (CNS) involvement. There were significant correlations between health-related quality of life score by SF-36v2 and depression by BDI-II score (mental component score: r = -0.617, p < 0.001; physical component score: r = -0.449, p = 0.010). Multiple linear regression analysis showed that the degree of depression was independently associated with mental health summary scale of SF-36v2 (B=−0.875; 95%CI −1.372 to −0.377; p = 0.001).
Conclusion: Our study suggested that the depression was common, and had a significant impact on the mental quality of life in patients with NMOSD.
Disclosure:
J.M.S: Nothing to disclose
M.C: Nothing to disclose
Y.S.K: Nothing to disclose
E.B.C: Nothing to disclose
H.L.L: Nothing to disclose
S.Y.K: Nothing to disclose
K.H.L: Nothing to disclose
B.J.K: Nothing to disclose
J.H.M: Nothing to disclose