Abstract: P269
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: Brain magnetic resonance imaging (MRI) lesions on T2-weighted or fluid-attenuated inversion recovery sequences are commonly seen in patients with neuromyelitis optica spectrum disorder (NMOsd). “Typical” NMO lesions are generally used with reference to lesions located at sites of high aquaporin 4 (AQP4) expressions. However, the exact frequency is unclear with differences between the regions that were evaluated.
Objectives: To report brain MRI characteristics (localization and configuration) abnormalities at diagnosis in a cohort of NMOsd Latin American patients.
Methods: Multicenter retrospective study from Argentina, Brazil and Venezuela that included 79 patients with NMOsd. We analyzed MRI characteristics at diagnosis using medical records database. Patients" demographic, clinical and laboratory data were collected.
Results: The prevalence of brain MRI abnormalities was 81.02% (64/79) at the onset of disease. Forty-two patients (53.17%) showed at least one kind of brain “typical” abnormality on MRI. Non-typical lesions were observed in 46.83% (37/79) and 59.45% (22/37) had nonspecific abnormalities. Characteristic brain MRI abnormalities were classified in lesions involving the dorsal medulla (area postrema, 16.46%), brainstem/cerebellum (32.91%,), hypothalamus (6.33%), thalamus (7.59%), periependymal surfaces of the third ventricle (11.39%), corticospinal tract lesions (8.86%), corpus callosum (13.92%), hemispheric white matter lesions (1.26%) and nonspecific white matter abnormalities (62.03%). Nine (11.39%) patients showed gadolinium-enhancing lesions. AQP4 antibody seropositive proportion was 63.63% (42/66) and non-available 16.46%. Characteristic brain MRI abnormalities do not differ significantly between seropositive and seronegative patients.
Conclusion: This study showed high frequency of brain typical MRI abnormalities and it is not associated with serological status. Recognize these lesions could help us differentiate multiple sclerosis of NMOds and early initiation of effective immunosuppressive therapy to preventing attack-related disability.
Disclosure: nothing to disclose
Abstract: P269
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: Brain magnetic resonance imaging (MRI) lesions on T2-weighted or fluid-attenuated inversion recovery sequences are commonly seen in patients with neuromyelitis optica spectrum disorder (NMOsd). “Typical” NMO lesions are generally used with reference to lesions located at sites of high aquaporin 4 (AQP4) expressions. However, the exact frequency is unclear with differences between the regions that were evaluated.
Objectives: To report brain MRI characteristics (localization and configuration) abnormalities at diagnosis in a cohort of NMOsd Latin American patients.
Methods: Multicenter retrospective study from Argentina, Brazil and Venezuela that included 79 patients with NMOsd. We analyzed MRI characteristics at diagnosis using medical records database. Patients" demographic, clinical and laboratory data were collected.
Results: The prevalence of brain MRI abnormalities was 81.02% (64/79) at the onset of disease. Forty-two patients (53.17%) showed at least one kind of brain “typical” abnormality on MRI. Non-typical lesions were observed in 46.83% (37/79) and 59.45% (22/37) had nonspecific abnormalities. Characteristic brain MRI abnormalities were classified in lesions involving the dorsal medulla (area postrema, 16.46%), brainstem/cerebellum (32.91%,), hypothalamus (6.33%), thalamus (7.59%), periependymal surfaces of the third ventricle (11.39%), corticospinal tract lesions (8.86%), corpus callosum (13.92%), hemispheric white matter lesions (1.26%) and nonspecific white matter abnormalities (62.03%). Nine (11.39%) patients showed gadolinium-enhancing lesions. AQP4 antibody seropositive proportion was 63.63% (42/66) and non-available 16.46%. Characteristic brain MRI abnormalities do not differ significantly between seropositive and seronegative patients.
Conclusion: This study showed high frequency of brain typical MRI abnormalities and it is not associated with serological status. Recognize these lesions could help us differentiate multiple sclerosis of NMOds and early initiation of effective immunosuppressive therapy to preventing attack-related disability.
Disclosure: nothing to disclose