Contributions
Abstract: P267
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Objective: The aim of this study was to investigate cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD) in Turkish population.
Methods: Twenty-two patients with the diagnosis of NMOSD according to the new criteria1 underwent neuropsychological tests (Brief Repetable Battery-Neuropsychology (BRB-N), Addenbrooke"s Cognitive Examination (ACE-R) and Beck Depression Invantery (BDI)). Cognitive impairment was considered if at least two cognitive domains were inferior to the 5th percentile for normal values for BRB-N test. The specificity and sensitivity of ACE-R test on detecting cognitive impairment were assessed through ACE-R test results.
Results: The mean age of the patients was 42,86±10,98 (25-65). 45,5% (n=10) of the patients had cognitive impairment and 50% (n=11) had depression. The group with cognitive impairment had significantly older age, lower educational status, higher EDSS and BDI scores. The mostly affected cognitive profile was found to be memory impairment, attention and processing dysfunction. When the specificity and sensitivity of ACE-R test on NMOSD patients were evaluated, diagnostic level of the test was found to be statistically good since it can detect cognitive impairment with a sensitivity of 88% and specificity of 75% on a cut off level of 82,5.
Conclusions: In our study, approximately half of the patients had depression or cognitive impairment. It has been concluded that ACE-R test can be used to detect cognitive impairment in NMOSD patients. Since cognitive impairment and depression are frequent in NMOSD patients, for their quality of life, it is important to evaluate these aspects of the disease.
References:
1- Wingerchuk DM, Banwell B, Bennett JL, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729.
Disclosure:
Burcu Altunrende: Nothing to disclose
Ahmet Yabalak: Nothing to disclose
Emrah Polat:Nothing to disclose
Meryem Kocaslan:Nothing to disclose
Bariş Topçular:Nothing to disclose
Gülşen Akman Demir:Nothing to disclose
Abstract: P267
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Objective: The aim of this study was to investigate cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD) in Turkish population.
Methods: Twenty-two patients with the diagnosis of NMOSD according to the new criteria1 underwent neuropsychological tests (Brief Repetable Battery-Neuropsychology (BRB-N), Addenbrooke"s Cognitive Examination (ACE-R) and Beck Depression Invantery (BDI)). Cognitive impairment was considered if at least two cognitive domains were inferior to the 5th percentile for normal values for BRB-N test. The specificity and sensitivity of ACE-R test on detecting cognitive impairment were assessed through ACE-R test results.
Results: The mean age of the patients was 42,86±10,98 (25-65). 45,5% (n=10) of the patients had cognitive impairment and 50% (n=11) had depression. The group with cognitive impairment had significantly older age, lower educational status, higher EDSS and BDI scores. The mostly affected cognitive profile was found to be memory impairment, attention and processing dysfunction. When the specificity and sensitivity of ACE-R test on NMOSD patients were evaluated, diagnostic level of the test was found to be statistically good since it can detect cognitive impairment with a sensitivity of 88% and specificity of 75% on a cut off level of 82,5.
Conclusions: In our study, approximately half of the patients had depression or cognitive impairment. It has been concluded that ACE-R test can be used to detect cognitive impairment in NMOSD patients. Since cognitive impairment and depression are frequent in NMOSD patients, for their quality of life, it is important to evaluate these aspects of the disease.
References:
1- Wingerchuk DM, Banwell B, Bennett JL, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729.
Disclosure:
Burcu Altunrende: Nothing to disclose
Ahmet Yabalak: Nothing to disclose
Emrah Polat:Nothing to disclose
Meryem Kocaslan:Nothing to disclose
Bariş Topçular:Nothing to disclose
Gülşen Akman Demir:Nothing to disclose