Contributions
Abstract: P261
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background and objective: The recently introduced International Consensus diagnostic criteria for diagnosis of neuromyelitis spectrum disorder include patients who are seronegative for AQP4 antibody. The criteria is dependent on typical MRI changes in the spinal cord, optic nerve and brain. This study aims to determine whether there are significant differences in the MRI brain images between AQP4 positive and negative patients with IIDDs
Method: MRI brain of patients with a diagnosis of IIDDs presented to the Hospital from 2010 to 2015 was analysed. The MRI was assessed by 2 radiologists blinded to the AQP4 status, on features said to be typical of NMOSD and MS.
Results: Thirty nine patients fulfilled the criteria and was included in the study. They consisted of 19 AQP4 seropositive and 20 AQP4 seronegative patients. The mean age was older (37.0 vs 28.8 years) among the AQP4 positive group. The majority of the patients were ethnic Chinese (72%), followed by the Malays and Indians. Those with AQP4 seropositive status generally has less brain lesions, with significantly less fulfilling the McDonald DIS criteria as compared with those with AQP4 seronegative status (15.8% vs 60.0%, p=0.004).
None of the seven cerebral MRI features highlighted in NMOSD 2015 diagnostic criteria, said to be characteristic of NMOSD was more common among the AQP4 positive patients. These features were in fact seen less frequently among the AQP4 seropositive patients. An example was the extensive hemispheric lesion seen in 10.5% of AQP4 seropositive patients vs 45% of those AQP4 seronegative group.
Conclusion: There was no characteristic MRI brain features in the Malaysian AQP4 seropositive IIDM patients versus those who are seronegative. This could be a reflection of ethnic difference.
Disclosure: This article is original and it has not been published. On behalf of all the authors, I declare that the enclosed manuscript in its present form has not been published elsewhere, in whole or in part.
The testing for serum anti AQP4 antibody was funded by the High Impact Research Grant (UM.C/HIR/MOHE/H-20001-E000037).
Abstract: P261
Type: Poster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background and objective: The recently introduced International Consensus diagnostic criteria for diagnosis of neuromyelitis spectrum disorder include patients who are seronegative for AQP4 antibody. The criteria is dependent on typical MRI changes in the spinal cord, optic nerve and brain. This study aims to determine whether there are significant differences in the MRI brain images between AQP4 positive and negative patients with IIDDs
Method: MRI brain of patients with a diagnosis of IIDDs presented to the Hospital from 2010 to 2015 was analysed. The MRI was assessed by 2 radiologists blinded to the AQP4 status, on features said to be typical of NMOSD and MS.
Results: Thirty nine patients fulfilled the criteria and was included in the study. They consisted of 19 AQP4 seropositive and 20 AQP4 seronegative patients. The mean age was older (37.0 vs 28.8 years) among the AQP4 positive group. The majority of the patients were ethnic Chinese (72%), followed by the Malays and Indians. Those with AQP4 seropositive status generally has less brain lesions, with significantly less fulfilling the McDonald DIS criteria as compared with those with AQP4 seronegative status (15.8% vs 60.0%, p=0.004).
None of the seven cerebral MRI features highlighted in NMOSD 2015 diagnostic criteria, said to be characteristic of NMOSD was more common among the AQP4 positive patients. These features were in fact seen less frequently among the AQP4 seropositive patients. An example was the extensive hemispheric lesion seen in 10.5% of AQP4 seropositive patients vs 45% of those AQP4 seronegative group.
Conclusion: There was no characteristic MRI brain features in the Malaysian AQP4 seropositive IIDM patients versus those who are seronegative. This could be a reflection of ethnic difference.
Disclosure: This article is original and it has not been published. On behalf of all the authors, I declare that the enclosed manuscript in its present form has not been published elsewhere, in whole or in part.
The testing for serum anti AQP4 antibody was funded by the High Impact Research Grant (UM.C/HIR/MOHE/H-20001-E000037).